dc.contributor.author
Ji, Xing
dc.contributor.author
Krüger, Henrike
dc.contributor.author
Tao, Jin
dc.contributor.author
Wang, Yaxin
dc.contributor.author
Fessler, Andrea T.
dc.contributor.author
Bai, Rina
dc.contributor.author
Wang, Shaolin
dc.contributor.author
Dong, Yanjun
dc.contributor.author
Shen, Jianzhong
dc.contributor.author
Schwarz, Stefan
dc.date.accessioned
2021-10-28T11:20:53Z
dc.date.available
2021-10-28T11:20:53Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32427
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-32151
dc.description.abstract
Methicillin-resistant Staphylococcus aureus (MRSA) of sequence types ST398 and ST9 are dominant lineages among livestock in Europe and Asia, respectively. Although both STs were commonly found as colonizers of the skin and the mucosal membranes, MRSA ST398, rather than MRSA ST9, has been reported to cause infections in humans and animals. Herein, we comparatively analyzed the genomic characteristics, fitness and virulence of MRSA ST398 and ST9 isolated from pigs in both China (CHN) and Germany (GER) to explore the factors that lead to differences in their epidemics and pathogenicity. We observed that the CHN-MRSA ST9 and the GER-MRSA ST9 have evolved independently, whereas the CHN-MRSA ST398 and GER-MRSA ST398 had close evolutionary relationships. Resistance to antimicrobial agents commonly used in livestock, the enhanced ability of biofilm formation, and the resistance to desiccation contribute to the success of the dominant clones of CHN-MRSA ST9 and GER-MRSA ST398, and the vwbνSaα gene on the genomic island might in part contribute to their colonization fitness in pigs. All MRSA ST398 strains revealed more diverse genome structures, higher tolerance to acids and high osmotic pressure, and greater competitive fitness in co-culture experiments. Notably, we identified and characterized a novel hysAνSaβ gene, which was located on the genomic island νSaβ of MRSA ST398 but was absent in MRSA ST9. The enhanced pathogenicity of the MRSA ST398 strains due to hysAνSaβ might in part explain why MRSA ST398 strains are more likely to cause infections.
en
dc.format.extent
14 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
Comparative analysis of genomic characteristics, fitness and virulence of MRSA ST398 and ST9 isolated from China and Germany
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1080/22221751.2021.1951125
dcterms.bibliographicCitation.journaltitle
Emerging Microbes & Infections
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.pagestart
1481
dcterms.bibliographicCitation.pageend
1494
dcterms.bibliographicCitation.volume
10
dcterms.bibliographicCitation.url
https://doi.org/10.1080/22221751.2021.1951125
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Mikrobiologie und Tierseuchen
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2222-1751
refubium.resourceType.provider
WoS-Alert