dc.contributor.author
Murk, Kai
dc.contributor.author
Ornaghi, Marta
dc.contributor.author
Schiweck, Juliane
dc.date.accessioned
2021-10-28T11:02:34Z
dc.date.available
2021-10-28T11:02:34Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32425
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-32149
dc.description.abstract
Profilins are small actin binding proteins, which are structurally conserved throughout evolution. They are probably best known to promote and direct actin polymerization. However, they also participate in numerous cell biological processes beyond the roles typically ascribed to the actin cytoskeleton. Moreover, most complex organisms express several profilin isoforms. Their cellular functions are far from being understood, whereas a growing number of publications indicate that profilin isoforms are involved in the pathogenesis of various diseases. In this review, we will provide an overview of the profilin family and "typical" profilin properties including the control of actin dynamics. We will then discuss the profilin isoforms of higher animals in detail. In terms of cellular functions, we will focus on the role of Profilin 1 (PFN1) and Profilin 2a (PFN2a), which are co-expressed in the central nervous system. Finally, we will discuss recent findings that link PFN1 and PFN2a to neurological diseases, such as amyotrophic lateral sclerosis (ALS), Fragile X syndrome (FXS), Huntington's disease and spinal muscular atrophy (SMA).
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
cytoskeleton
en
dc.subject
central nervous system
en
dc.subject
amyotrophic lateral sclerosis
en
dc.subject
Fragile X syndrome
en
dc.subject
Huntington's disease
en
dc.subject
spinal muscular atrophy
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Profilin Isoforms in Health and Disease – All the Same but Different
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
681122
dcterms.bibliographicCitation.doi
10.3389/fcell.2021.681122
dcterms.bibliographicCitation.journaltitle
Frontiers in Cell and Developmental Biology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
9
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
34458253
dcterms.isPartOf.eissn
2296-634X