dc.contributor.author
Ihlow, Jana
dc.contributor.author
Michaelis, Edward
dc.contributor.author
Greuel, Selina
dc.contributor.author
Heynol, Verena
dc.contributor.author
Lehmann, Annika
dc.contributor.author
Radbruch, Helena
dc.contributor.author
Meinhardt, Jenny
dc.contributor.author
Miller, Florian
dc.contributor.author
Herbst, Hermann
dc.contributor.author
Corman, Victor Max
dc.contributor.author
Westermann, Jörg
dc.contributor.author
Bullinger, Lars
dc.contributor.author
Horst, David
dc.contributor.author
Brünneck, Ann-Christin von
dc.contributor.author
Elezkurtaj, Sefer
dc.date.accessioned
2021-10-11T11:42:28Z
dc.date.available
2021-10-11T11:42:28Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32265
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31992
dc.description.abstract
Objectives: In coronavirus disease 2019 (COVID-19), the adaptive immune response is of considerable importance, and detailed cellular immune reactions in the hematological system of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are yet to be clarified.
Methods: This study reports the morphological characterization of both bone marrow and spleen in 11 COVID-19 decedents with respect to findings in the peripheral blood and pulmonary SARS-CoV-2 burden.
Results: In the bone marrow, activation and left shift were found in at least 55% of patients, which was mirrored by peripheral anaemia, granulocytic immaturity and multiple thromboembolic events. Signs of sepsis-acquired immunodeficiency were found in the setting of an abscess-forming superinfection of viral COVID-19 pneumonia. Furthermore, a severe B cell loss was observed in the bone marrow and/or spleen in 64% of COVID-19 patients. This was reflected by lymphocytopenia in the peripheral blood. As compared to B cell preservation, B cell loss was associated with a higher pulmonary SARS-CoV-2 burden and only a marginal decrease of of T cell counts.
Conclusions: The results of this study suggest the presence of sepsis-related immunodeficiency in severe COVID-19 pneumonia with superinfection. Furthermore, our findings indicate that lymphocytopenia in COVID-19 is accompanied by B cell depletion in hematopoietic tissue, which might impede the durability of the humoral immune response to SARS-CoV-2. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Immunodeficiency
en
dc.subject
Humoral immune response
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
B cell depletion and signs of sepsis-acquired immunodeficiency in bone marrow and spleen of COVID-19 deceased
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1016/j.ijid.2020.12.078
dcterms.bibliographicCitation.journaltitle
International Journal of Infectious Diseases
dcterms.bibliographicCitation.originalpublishername
Elsevier
dcterms.bibliographicCitation.pagestart
628
dcterms.bibliographicCitation.pageend
635
dcterms.bibliographicCitation.volume
103
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33401036
dcterms.isPartOf.eissn
1878-3511