dc.contributor.author
Constantinou, Andria
dc.contributor.author
Kanti, Varvara
dc.contributor.author
Polak-Witka, Katarzyna
dc.contributor.author
Blume-Peytavi, Ulrike
dc.contributor.author
Spyrou, George M.
dc.contributor.author
Vogt, Annika
dc.date.accessioned
2021-10-05T13:13:02Z
dc.date.available
2021-10-05T13:13:02Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32200
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31928
dc.description.abstract
Human skin and hair follicles are recognized sites of microbial colonization. These microbiota help regulate host immune mechanisms via an interplay between microbes and immune cells, influencing homeostasis and inflammation. Bacteria affect immune responses by controlling the local inflammatory milieu, the breakdown of which can result in chronic inflammatory disorders. Follicular microbiome shifts described in some inflammatory cutaneous diseases suggest a link between their development or perpetuation and dysbiosis. Though the hair follicle infundibulum is an area of intense immunological interactions, bulb and bulge regions represent immune-privileged niches. Immune privilege maintenance seems essential for hair growth and regeneration, as collapse and inflammation characterize inflammatory hair disorders like alopecia areata and primary cicatricial alopecia. Current research largely focuses on immunological aberrations. However, studies suggest that external stimuli and interactions across the follicular epithelium can have profound effects on the local immune system, homeostasis, and cycling. Herein, we review hair follicle bacterial colonization, its possible effects on the underlying tissue, and links to the pathogenesis of alopecia, beyond the pure investigation of specific species abundance. As skin microbiology enters the metagenomics era, multi-dimensional approaches will enable a new level of investigations on the effects of microorganisms and metabolism on host tissue.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
follicular microbiome
en
dc.subject
hair follicle
en
dc.subject
hair disease
en
dc.subject
metagenomics
en
dc.subject
next generation sequencing
en
dc.subject
bioinformatics
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
The Potential Relevance of the Microbiome to Hair Physiology and Regeneration: The Emerging Role of Metagenomics
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
236
dcterms.bibliographicCitation.doi
10.3390/biomedicines9030236
dcterms.bibliographicCitation.journaltitle
Biomedicines
dcterms.bibliographicCitation.number
3
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
9
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33652789
dcterms.isPartOf.eissn
2227-9059