dc.contributor.author
Ginter, Katharina
dc.contributor.author
Ahsan, Dalia Melina
dc.contributor.author
Bizjak, Mojca
dc.contributor.author
Krause, Karoline
dc.contributor.author
Maurer, Marcus
dc.contributor.author
Altrichter, Sabine
dc.contributor.author
Terhorst-Molawi, Dorothea
dc.date.accessioned
2021-09-30T12:55:37Z
dc.date.available
2021-09-30T12:55:37Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32134
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31862
dc.description.abstract
Introduction Cryoproteins, such as cryoglobulins, cryofibrinogens and cold agglutinins, precipitate at low temperatures or agglutinate erythrocytes and dissolve again when warmed. Their pathogenetic and diagnostic importance in cold urticaria (ColdU) is unclear. In this study, we aimed to characterize the prevalence of cryoproteins in patients with ColdU. Methods We conducted 3 analyses: i) a systematic review and meta-analysis of published data using an adapted version of the Joanna Briggs Institute's critical appraisal tool for case series, ii) a retrospective analysis of 293 ColdU patients treated at our Urticaria Center of Reference and Excellence (UCARE) from 2014 to 2019, and iii) a prospective observational study, from July 2019 to July 2020, with 49 ColdU patients as defined by the EAACI/GA2LEN/EDF/UNEV consensus recommendations. Results Our systematic review identified 14 relevant studies with a total of 1151 ColdU patients. The meta-analyses showed that 3.0% (19/628), 1.1% (4/357) and 0.7% (2/283) of patients had elevated levels of cryoglobulins, cryofibrinogens and cold agglutinins, respectively. Our retrospective analyses showed that cryoproteins were assessed in 4.1% (12/293) of ColdU patients. None of 9 ColdU patients had cryoglobulins, and one of 5 had cold agglutinins. In our prospective study, none of our patients had detectable cryoglobulins (0/48) or cryofibrinogens (0/48), but 4.3% (2/46) of patients had cold agglutinins (without any known underlying autoimmune or hematological disorder). Conclusion Our investigation suggests that only very few ColdU patients exhibit cryoproteins and that the pathogenesis of ColdU is driven by other mechanisms, which remain to be identified and characterized in detail.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
cold urticaria
en
dc.subject
cryoglobulins
en
dc.subject
cryofibrinogens
en
dc.subject
cold agglutinins
en
dc.subject
cryoproteins
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Cryoglobulins, Cryofibrinogens, and Cold Agglutinins in Cold Urticaria: Literature Review, Retrospective Patient Analysis, and Observational Study in 49 Patients
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
675451
dcterms.bibliographicCitation.doi
10.3389/fimmu.2021.675451
dcterms.bibliographicCitation.journaltitle
Frontiers in Immunology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
12
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
34113348
dcterms.isPartOf.eissn
1664-3224