dc.contributor.author
Mendt, Stefan
dc.contributor.author
Brauns, Katharina
dc.contributor.author
Friedl-Werner, Anika
dc.contributor.author
Belavy, Daniel L.
dc.contributor.author
Steinach, Mathias
dc.contributor.author
Schlabs, Thomas
dc.contributor.author
Werner, Andreas
dc.contributor.author
Gunga, Hanns-Christian
dc.contributor.author
Stahn, Alexander C.
dc.date.accessioned
2021-09-29T15:00:04Z
dc.date.available
2021-09-29T15:00:04Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32108
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31836
dc.description.abstract
Spaceflight can be associated with sleep loss and circadian misalignment as a result of non-24 h light-dark cycles, operational shifts in work/rest cycles, high workload under pressure, and psychological factors. Head-down tilt bed rest (HDBR) is an established model to mimic some of the physiological and psychological adaptions observed in spaceflight. Data on the effects of HDBR on circadian rhythms are scarce. To address this gap, we analyzed the change in the circadian rhythm of core body temperature (CBT) in two 60-day HDBR studies sponsored by the European Space Agency [n = 13 men, age: 31.1 +/- 8.2 years (M +/- SD)]. CBT was recorded for 36 h using a non-invasive and validated dual-sensor heatflux technology during the 3rd and the 8th week of HDBR. Bed rest induced a significant phase delay from the 3rd to the 8th week of HDBR (16.23 vs. 16.68 h, p = 0.005, g = 0.85) irrespective of the study site (p = 0.416, g = -0.46), corresponding to an average phase delay of about 0.9 min per day of HDBR. In conclusion, long-term bed rest weakens the entrainment of the circadian system to the 24-h day. We attribute this effect to the immobilization and reduced physical activity levels associated with HDBR. Given the critical role of diurnal rhythms for various physiological functions and behavior, our findings highlight the importance of monitoring circadian rhythms in circumstances in which gravity or physical activity levels are altered.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
medical care
en
dc.subject
deconditioning
en
dc.subject
countermeasure
en
dc.subject
core body temperature
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Long-Term Bed Rest Delays the Circadian Phase of Core Body Temperature
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
658707
dcterms.bibliographicCitation.doi
10.3389/fphys.2021.658707
dcterms.bibliographicCitation.journaltitle
Frontiers in Physiology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
12
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
34040542
dcterms.isPartOf.eissn
1664-042X