dc.contributor.author
Bartsch, Julia C.
dc.contributor.author
Cramon, Monique von
dc.contributor.author
Gruber, David
dc.contributor.author
Heinemann, Uwe
dc.contributor.author
Behr, Joachim
dc.date.accessioned
2021-09-28T06:36:13Z
dc.date.available
2021-09-28T06:36:13Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32079
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31807
dc.description.abstract
Stress is a biologically relevant signal and can modulate hippocampal synaptic plasticity. The subiculum is the major output station of the hippocampus and serves as a critical hub in the stress response network. However, stress-associated synaptic plasticity in the ventral subiculum has not been adequately addressed. Therefore, we investigated the impact of a single exposure to an inherently stressful two-way active avoidance conditioning on the induction of long-term potentiation (LTP) at CA1-subiculum synapses in ventral hippocampal slices from young adult rats 1 day after stressor exposure. We found that acute stress enhanced LTP and lowered the induction threshold for a late-onset LTP at excitatory CA1 to subicular burst-spiking neuron synapses. This late-onset LTP was dependent on the activation of beta-adrenergic and glutamatergic N-methyl-D-aspartate receptors and independent of D1/D5 dopamine receptor activation. Thereby, we present a cellular mechanism that might contribute to behavioral stress adaptation after acute stressor exposure.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
long-term potentiation
en
dc.subject
norepinephrine
en
dc.subject
metaplasticity
en
dc.subject
β-adrenergic receptor
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Stress-Induced Enhanced Long-Term Potentiation and Reduced Threshold for N-Methyl-D-Aspartate Receptor- and β-Adrenergic Receptor-Mediated Synaptic Plasticity in Rodent Ventral Subiculum
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
658465
dcterms.bibliographicCitation.doi
10.3389/fnmol.2021.658465
dcterms.bibliographicCitation.journaltitle
Frontiers in Molecular Neuroscience
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
14
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33967694
dcterms.isPartOf.eissn
1662-5099