dc.contributor.author
Schneider-Burrus, Sylke
dc.contributor.author
Tsaousi, Athanasia
dc.contributor.author
Barbus, Sebastian
dc.contributor.author
Huss-Marp, Johannes
dc.contributor.author
Witte, Katrin
dc.contributor.author
Wolk, Kerstin
dc.contributor.author
Fritz, Björn
dc.contributor.author
Sabat, Robert
dc.date.accessioned
2021-09-27T08:27:07Z
dc.date.available
2021-09-27T08:27:07Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32058
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31786
dc.description.abstract
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with an adverse impact on patients' quality of life (QoL).
Objectives: To quantify QoL impairment in patients in Germany suffering from HS and to identify the parameters associated with QoL impairment.
Methods: A non-interventional, cross-sectional, mono-centric study with 500 HS patients. QoL data (measured using the Dermatology Life Quality Index; DLQI) and demographic, anamnestic, clinical, and blood parameters were collected. All patients were examined by dermatologists that documented the skin alterations. QoL data from 462 HS patients were available and evaluated.
Results: The mean (+/- standard deviation) DLQI score of HS patients was 13.18 +/- 7.99. Approximately 40% and 20% of HS patients declared very large and extremely large QoL impairment, respectively. The degree of QoL disturbance correlated with the severity of skin alterations, blood leucocyte count and, in particular, with anogenital localization and the presence of nodules and fistulas. Furthermore, QoL impairment was associated with specific comorbidities, such as adiposity and back pain, but not with HS family history. QoL impairment was not influenced by whether or not the patients had undergone resection surgery or antibiotic treatment but was more severe in HS patients that had undergone abscess lancing compared to patients without such treatment in the past.
Limitations: It was a mono-centric study and most data were obtained from self-administered patient questionnaires. The association of QoL with type of treatment was analyzed for abscess lancing, resection surgery, and antibiotic treatment. Further therapeutic modalities recommended in the guidelines were not investigated.
Conclusion: A profound impairment in QoL was present in patients with HS, and this was higher than that observed in other studied dermatoses. The degree of impairment correlated with the extent of cutaneous and some extra-cutaneous alterations. Surgical and conventional medicamentous therapies of HS were not associated with long-lasting reduction of QoL impairment. Our data support the implementation of patient-reported outcome measures for the assessment of therapy responses.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
skin disease
en
dc.subject
quality of life
en
dc.subject
dermatology life quality index
en
dc.subject
spondyloarthritis
en
dc.subject
metabolic syndrome
en
dc.subject
family history
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Features Associated With Quality of Life Impairment in Hidradenitis Suppurativa Patients
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
676241
dcterms.bibliographicCitation.doi
10.3389/fmed.2021.676241
dcterms.bibliographicCitation.journaltitle
Frontiers in Medicine
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
8
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33987196
dcterms.isPartOf.eissn
2296-858X