dc.contributor.author
Stömmer, Pierre
dc.contributor.author
Kiefer, Henrik
dc.contributor.author
Kopperger, Enzo
dc.contributor.author
Honemann, Maximilian N.
dc.contributor.author
Kube, Massimo
dc.contributor.author
Simmel, Friedrich C.
dc.contributor.author
Netz, Roland R.
dc.contributor.author
Dietz, Hendrik
dc.date.accessioned
2021-09-09T07:55:21Z
dc.date.available
2021-09-09T07:55:21Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/31903
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31635
dc.description.abstract
Creating artificial macromolecular transport systems that can support the movement of molecules along defined routes is a key goal of nanotechnology. Here, we report the bottom-up construction of a macromolecular transport system in which molecular pistons diffusively move through micrometer-long, hollow filaments. The pistons can cover micrometer distances in fractions of seconds. We build the system using multi-layer DNA origami and analyze the structures of the components using transmission electron microscopy. We study the motion of the pistons along the tubes using single-molecule fluorescence microscopy and perform Langevin simulations to reveal details of the free energy surface that directs the motions of the pistons. The tubular transport system achieves diffusivities and displacement ranges known from natural molecular motors and realizes mobility improvements over five orders of magnitude compared to previous artificial random walker designs. Electric fields can also be employed to actively pull the pistons along the filaments, thereby realizing a nanoscale electric rail system. Our system presents a platform for artificial motors that move autonomously driven by chemical fuels and for performing nanotribology studies, and it could form a basis for future molecular transportation networks.
en
dc.format.extent
10 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
DNA nanotechnology
en
dc.subject
synthetic tubular molecular transport system
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::530 Physik::530 Physik
dc.title
A synthetic tubular molecular transport system
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
4393
dcterms.bibliographicCitation.doi
10.1038/s41467-021-24675-8
dcterms.bibliographicCitation.journaltitle
Nature Communications
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.volume
12
dcterms.bibliographicCitation.url
https://doi.org/10.1038/s41467-021-24675-8
refubium.affiliation
Physik
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2041-1723
refubium.resourceType.provider
WoS-Alert