dc.contributor.author
Stippl, Anna
dc.contributor.author
Kirkgöze, Fatma Nur
dc.contributor.author
Bajbouj, Malek
dc.contributor.author
Grimm, Simone
dc.date.accessioned
2021-09-03T12:48:30Z
dc.date.available
2021-09-03T12:48:30Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/31819
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31552
dc.description.abstract
Background/Aims/Methods: Electroconvulsive therapy (ECT) is still one of the most potent treatments in the acute phase of major depressive disorder (MDD) and particularly applied in patients considered treatment resistant. However, despite the frequent and widespread use of ECT for >70 years, the exact neurobiological mechanisms underlying its efficacy remain unclear. The present review aims to describe differential antidepressant and cognitive effects of ECT as well as effects on markers of neural activity and connectivity, neurochemistry, and inflammation that might underlie the treatment response and remission.
Results: Region- specific changes in brain function and volume along with changes in concentrations of neurotransmitters and neuroinflammatory cytokines might serve as potential biomarkers for ECT outcomes.
Conclusions: However, as current data is not consistent, future longitudinal investigations should combine modalities such as MRI, MR spectroscopy, and peripheral physiological measures to gain a deeper insight into interconnected time- and modality-specific changes in response to ECT.
en
dc.subject
Electroconvulsive therapy
en
dc.subject
Major depressive disorder
en
dc.subject
Antidepressant efficacy
en
dc.subject
Neurobiological markers of ECT response
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Differential Effects of Electroconvulsive Therapy in the Treatment of Major Depressive Disorder
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1159/000505553
dcterms.bibliographicCitation.journaltitle
Neuropsychobiology
dcterms.bibliographicCitation.number
6
dcterms.bibliographicCitation.originalpublishername
Karger
dcterms.bibliographicCitation.pagestart
408
dcterms.bibliographicCitation.pageend
416
dcterms.bibliographicCitation.volume
79
dcterms.rightsHolder.note
Copyright applies in this work.
dcterms.rightsHolder.url
http://rightsstatements.org/vocab/InC/1.0/
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.note.author
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
de
refubium.note.author
This publication is shared with permission of the rights owner and made freely accessible through a DFG (German Research Foundation) funded license at either an alliance or national level.
en
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32344410
dcterms.isPartOf.issn
0302-282X
dcterms.isPartOf.eissn
1423-0224