dc.contributor.author
Martín, Adrián López
dc.contributor.author
Mounir, Mohamed
dc.contributor.author
Meyer, Irmtraud M.
dc.date.accessioned
2021-08-09T12:39:51Z
dc.date.available
2021-08-09T12:39:51Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/31568
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31300
dc.description.abstract
RNA structure formation in vivo happens co-transcriptionally while the transcript is being made. The corresponding co-transcriptional folding pathway typically involves transient RNA structure features that are not part of the final, functional RNA structure. These transient features can play important functional roles of their own and also influence the formation of the final RNA structure in vivo. We here present CoBold, a computational method for identifying different functional classes of transient RNA structure features that can either aid or hinder the formation of a known reference RNA structure. Our method takes as input either a single RNA or a corresponding multiple-sequence alignment as well as a known reference RNA secondary structure and identifies different classes of transient RNA structure features that could aid or prevent the formation of the given RNA structure. We make CoBold available via a web-server which includes dedicated data visualisation.
en
dc.format.extent
14 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
Nucleic acid structure
en
dc.subject
Computational Methods
en
dc.subject
RNA structure formation
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
CoBold: a method for identifying different functional classes of transient RNA structure features that can impact RNA structure formation in vivo
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e19
dcterms.bibliographicCitation.doi
10.1093/nar/gkaa900
dcterms.bibliographicCitation.journaltitle
Nucleic Acids Research
dcterms.bibliographicCitation.number
4
dcterms.bibliographicCitation.volume
49
dcterms.bibliographicCitation.url
https://doi.org/10.1093/nar/gkaa900
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1362-4962
refubium.resourceType.provider
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