dc.contributor.author
Mergenthaler, Philipp
dc.contributor.author
Meisel, Andreas
dc.date.accessioned
2021-08-03T08:23:07Z
dc.date.available
2021-08-03T08:23:07Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/31381
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31114
dc.description.abstract
Modern biomedical research with the aim of translating research findings into novel therapies to benefit patients relies to a large extent on animal models of human pathophysiology. However, success stories of translational research – i.e. preclinical research that successfully predicts positive outcome of a clinical trial – are scarce. Here, we therefore address the current state of preclinical disease modeling as well as actions that have been taken to improve the translational value of animal models.
en
dc.rights.uri
http://www.fu-berlin.de/sites/refubium/rechtliches/Nutzungsbedingungen
dc.subject
animal models
en
dc.subject
pathophysiology
en
dc.subject
disease mechanisms
en
dc.subject
preclinical randomized controlled trials
en
dc.subject
modeling of care
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::618 Experimentelle Medizin
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Animal Models: Value and Translational Potency
dc.title.subtitle
Chapter 8
dcterms.bibliographicCitation.booktitle
Principles of Translational Science in Medicine - From Bench to Bedside
dcterms.bibliographicCitation.doi
10.1016/B978-0-12-820493-1.00028-3
dcterms.bibliographicCitation.issue
Third Edition
dcterms.bibliographicCitation.originalpublishername
Elsevier
dcterms.bibliographicCitation.pagestart
95
dcterms.bibliographicCitation.pageend
103
dcterms.rightsHolder.note
Copyright © 2021 Elsevier B.V. All rights reserved.
dcterms.rightsHolder.note
Correspondence from publisher: "The terms of the contributor agreement allows authors to post their final (not formatted) Word draft of the chapter to their institution’s repository."
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.note.author
Original book chapter first published: 2021-07-23.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.isbn
978-0-12-820493-1
