dc.contributor.author
Denner, Joachim
dc.date.accessioned
2021-06-24T08:35:28Z
dc.date.available
2021-06-24T08:35:28Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/31133
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-30869
dc.description.abstract
Porcine lymphotropic herpesviruses -1, -2 and -3 (PLHV-1, PLHV-2 and PLHV-3) are gammaherpesviruses which are widespread in pigs. They are closely related to the Epstein–Barr virus (EBV) and Kaposi sarcoma herpesvirus, both of which cause severe diseases in humans. PLHVs are also related to bovine and ovine gammaherpesviruses, which are apathogenic in the natural host, but cause severe diseases after transmission into other species. Until now, no association between PLHVs and any pig diseases had been described. However, PLHV-1 causes a post-transplantation lymphoproliferative disorder (PTLD) after experimental transplantations in minipigs. This disorder is similar to human PTLD, a serious complication of solid human organ transplantation linked to EBV. Xenotransplantation using pig cells, tissues and organs is under development in order to alleviate the shortage of human transplants. Meanwhile, remarkable survival times of pig xenotransplants in non-human primates have been achieved. In these preclinical trials, another pig herpesvirus, the porcine cytomegalovirus (PCMV), a roseolovirus, was shown to significantly reduce the survival time of pig xenotransplants in baboons and other non-human primates. Although PLHV-1 was found in genetically modified donor pigs used in preclinical xenotransplantation, it was, in contrast to PCMV, not transmitted to the recipient. Nevertheless, it seems important to use PLHV-free donor pigs in order to achieve safe xenotransplantation.
en
dc.format.extent
6 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
porcine lymphotropic herpesviruses
en
dc.subject
xenotransplantation
en
dc.subject
orcine cytomegalovirus
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
dc.title
Porcine Lymphotropic Herpesviruses (PLHVs) and Xenotranplantation
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1072
dcterms.bibliographicCitation.doi
10.3390/v13061072
dcterms.bibliographicCitation.journaltitle
Viruses
dcterms.bibliographicCitation.number
6
dcterms.bibliographicCitation.originalpublishername
MDPI
dcterms.bibliographicCitation.volume
13
dcterms.bibliographicCitation.url
https://doi.org/10.3390/v13061072
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Virologie
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refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
de
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1999-4915