dc.contributor.author
Burkhardt, Wiebke
dc.contributor.author
Rausch, Theresa
dc.contributor.author
Klopfleisch, Robert
dc.contributor.author
Blaut, Michael
dc.contributor.author
Braune, Annett
dc.date.accessioned
2021-06-21T14:01:24Z
dc.date.available
2021-06-21T14:01:24Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/31101
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-30837
dc.description.abstract
The interplay between diet, intestinal microbiota and host is a major factor impacting health. A diet rich in unsaturated fatty acids has been reported to stimulate the growth of Bilophila wadsworthia by increasing the proportion of the sulfonated bile acid taurocholate (TC). The taurine-induced overgrowth of B. wadsworthia promoted the development of colitis in interleukin-10-deficient (IL-10-/-) mice. This study aimed to investigate whether intake of the sulfonates sulfoquinovosyl diacylglycerols (SQDG) with a dietary supplement or their degradation product sulfoquinovose (SQ), stimulate the growth of B. wadsworthia in a similar manner and, thereby, cause intestinal inflammation. Conventional IL-10-/- mice were fed a diet supplemented with the SQDG-rich cyanobacterium Arthrospira platensis (Spirulina). SQ or TC were orally applied to conventional IL-10-/- mice and gnotobiotic IL-10-/- mice harboring a simplified human intestinal microbiota with or without B. wadsworthia. Analyses of inflammatory parameters revealed that none of the sulfonates induced severe colitis, but both, Spirulina and TC, induced expression of pro-inflammatory cytokines in cecal mucosa. Cell numbers of B. wadsworthia decreased almost two orders of magnitude by Spirulina feeding but slightly increased in gnotobiotic SQ and conventional TC mice. Changes in microbiota composition were observed in feces as a result of Spirulina or TC feeding in conventional mice. In conclusion, the dietary sulfonates SQDG and their metabolite SQ did not elicit bacteria-induced intestinal inflammation in IL-10-/- mice and, thus, do not promote colitis.
en
dc.format.extent
11 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Sulfoquinovose
en
dc.subject
Inflammatory bowel disease
en
dc.subject
Bilophila wadsworthia
en
dc.subject
Taurocholate
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
Impact of dietary sulfolipid-derived sulfoquinovose on gut microbiota composition and inflammatory status of colitis-prone interleukin-10-deficient mice
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
151494
dcterms.bibliographicCitation.doi
10.1016/j.ijmm.2021.151494
dcterms.bibliographicCitation.journaltitle
International Journal of Medical Microbiology
dcterms.bibliographicCitation.number
3
dcterms.bibliographicCitation.volume
311
dcterms.bibliographicCitation.url
https://doi.org/10.1016/j.ijmm.2021.151494
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Tierpathologie

refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1438-4221
refubium.resourceType.provider
WoS-Alert