dc.contributor.author
Jeuthe, Sarah
dc.contributor.author
Kemna, Josephine
dc.contributor.author
Kemna, Christoph Philipp
dc.contributor.author
Zocholl, Dario
dc.contributor.author
Klopfleisch, Robert
dc.contributor.author
Palme, Rupert
dc.contributor.author
Kirschbaum, Clemens
dc.contributor.author
Thoene-Reineke, Christa
dc.contributor.author
Kammertoens, Thomas
dc.date.accessioned
2021-04-26T09:59:01Z
dc.date.available
2021-04-26T09:59:01Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/30544
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-30284
dc.description.abstract
It is controversially discussed whether immune-deficient mice experience severity in the absence of infection. Because a comprehensive analysis of the well-being of immune-deficient mice under specific pathogen free conditions is missing, we used a multi-parametric test analyzing, corticosterone, weight, nest building and facial expression over a period of 9 month to determine the well-being of two immune-deficient mouse lines (recombination activating gene 2- and interferon gamma receptor-deficient mice). We do not find evidence for severity when comparing immune-deficient mice to their heterozygous immune-competent littermates. Our data challenge the assumption that immune-deficiency per se regardless of housing conditions causes severity. Based on our study we propose to use objective non-invasive parameters determined by laboratory animal science for decisions concerning severity of immune-deficient mice.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
B-Lymphocytes
en
dc.subject
Corticosterone
en
dc.subject
DNA-Binding Proteins
en
dc.subject
Receptors, Interferon
en
dc.subject
Signal Transduction
en
dc.subject
T-Lymphocytes
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Stress hormones or general well-being are not altered in immune-deficient mice lacking either T- and B- lymphocytes or Interferon gamma signaling if kept under specific pathogen free housing conditions
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e0239231
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0239231
dcterms.bibliographicCitation.journaltitle
PLOS ONE
dcterms.bibliographicCitation.number
9
dcterms.bibliographicCitation.originalpublishername
Public Library of Science (PLoS)
dcterms.bibliographicCitation.volume
15
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32997686
dcterms.isPartOf.eissn
1932-6203