dc.contributor.author
Kaczmarczyk, Michael
dc.contributor.author
Spitzer, Carsten
dc.contributor.author
Wingenfeld, Katja
dc.contributor.author
Wiedemann, Klaus
dc.contributor.author
Kuehl, Linn K.
dc.contributor.author
Schultebraucks, Katharina
dc.contributor.author
Deuter, Christian Eric
dc.contributor.author
Otte, Christian
dc.date.accessioned
2021-04-09T13:10:00Z
dc.date.available
2021-04-09T13:10:00Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/30288
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-30029
dc.description.abstract
Background: Adverse childhood experiences (ACE) are associated with an increased risk of major depressive disorder (MDD) and hypothalamic-pituitary-adrenal (HPA) axis dysregulation. Within the HPA axis, corticotropin-releasing hormone and vasopressin (AVP) synergistically stimulate the release of adrenocorticotropic hormone, which promotes cortisol release. The cleavage product copeptin is produced during AVP synthesis and is a surrogate marker of AVP release. Children with ACE and young adults with depressive symptoms have higher levels of copeptin than healthy controls. Objective: To uncover the effects of MDD and ACE on copeptin levels in adult females. Methods: We recruited 94 women (mean age: 34.0 +/- 3.6 years): 23 with MDD and ACE, 24 with MDD without ACE, 22 with ACE without MDD, and 25 healthy controls. ACE was defined as repeated sexual or physical abuse at least once a month over at least one year before the age of 18 years. MDD was defined by the DSM-IV criteria. Copeptin plasma levels were measured with an immunoluminometric assay. Results: The four groups did not differ in demographic variables. We found a significant negative correlation between body mass index (BMI) and copeptin plasma levels (r = -.21; p = .045). Copeptin plasma levels did not differ between the four groups after controlling for BMI. Conclusion: Neither MDD nor ACE was associated with altered plasma copeptin levels. Thus, copeptin does not seem to play a major role in MDD and ACE in adult females.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
major depressive disorder
en
dc.subject
adverse childhood experiences
en
dc.subject
body mass index
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
No association between major depression with and without childhood adversity and the stress hormone copeptin
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1837511
dcterms.bibliographicCitation.doi
10.1080/20008198.2020.1837511
dcterms.bibliographicCitation.journaltitle
European Journal of Psychotraumatology
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
Taylor & Francis
dcterms.bibliographicCitation.volume
11
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33244366
dcterms.isPartOf.issn
2000-8198
dcterms.isPartOf.eissn
2000-8066