Cognitive biases, such as adversarial allegiance, can compromise expert witness evaluations and contribute to wrongful convictions. Therefore, the application of debiasing strategies is essential. The Analysis of Competing Hypotheses (ACH) has been proposed as a potential method to reduce such bias, although empirical support remains limited. The present study investigated the effectiveness of the ACH method in mitigating adversarial allegiance in a sample of mock expert witnesses for credibility assessments. In an online experiment, 159 participants with prior knowledge in credibility assessments reviewed a summary of a child sexual abuse case. Before reviewing the case material, participants were randomly assigned to one of three retaining party conditions: defense, accessory prosecution, or court. Next, half of the participants were instructed to apply the ACH method which includes the systematic comparison of alternative hypotheses within a matrix. Meanwhile the control group was instructed to follow the standard approach in credibility assessments in Germany, which includes the evaluation and falsification of alternative hypotheses, albeit in a less structured way than the ACH method. Outcomes were assessed using credibility ratings and an Evidence Score, the latter reflecting the extent to which participants weighed evidence in favor of their retaining party or evaluated information more evenly. No significant differences emerged in credibility ratings across conditions. However, adversarial allegiance was evident in the Evidence Score: defense-retained participants emphasized evidence undermining the statement’s credibility more than those retained by the accessory prosecution. At the same time, the application of the ACH method did not significantly influence credibility ratings or evidence selection. Overall, these findings suggest that the ACH method may have limited utility as a debiasing strategy in the context of credibility assessments and underscore the challenges of mitigating bias in forensic decision-making.

The climatic impact of maritime stratocumulus clouds depends on the evolution of their droplet size distribution (DSD), yet the mechanisms controlling their variability during evaporation remain poorly constrained. Using large-eddy simulations coupled with a Lagrangian cloud model, we demonstrate that the DSD evolution follows two primary regimes: adiabatic growth and entrainment–descent. Within the latter, DSD evolution follows divergent pathways determined by the parcel's entrainment history: strong entrainment-driven dilution near the cloud top causes rapid broadening, whereas large-scale boundary-layer descent leads to gradual evaporation. Our Lagrangian analysis of the Damköhler number reveals that the commonly observed vertical transition from inhomogeneous to homogeneous mixing signatures does not necessarily reflect a change in the local mixing mechanism. Instead, it results from the vertical sorting of parcels with divergent histories. Parcels subject to strong entrainment retain inhomogeneous signatures throughout their descent, while those experiencing minimal dilution exhibit homogeneous-like characteristics regardless of altitude. This distinction helps resolve ambiguities in interpreting in situ observations where mixing history is often unknown. Finally, we propose a combined analytical–empirical formulation that captures the relative dispersion during both growth and evaporation.

Humans and other land vertebrates localize sound by comparing the signals in each ear. Even though these differences are virtually absent underwater, fish are still able to sense the direction of sound. In 1975, Arie Schuijf proposed that this ability could arise from a comparison of the particle motion phase and the pressure phase of sound, a prediction that was recently confirmed experimentally for near-field sounds. However, in natural environments, sounds arrive from variable distances, altering the motion-pressure-phase relationship. Thus, directional hearing and distance hearing are potentially in conflict. There is currently neither a model nor experimental data for how fish deal with this complexity. Here, we systematically introduce phase differences between the particle motion and pressure components of sound pulses to quantify the directional tuning of startle responses in Danionella cerebrum. We find that the fish's directed startle behavior is both frequency and phase dependent, and we introduce a new model that quantitatively predicts the sensorimotor transformation across all observed stimuli. This framework likely extends to other otophysan fishes with evolutionarily conserved hearing apparatus, representing ∼15% of all vertebrate species.

Objective: Persisting neurological symptoms after COVID-19 affect up to 10% of patients and can manifest in fatigue and cognitive complaints. Based on recent evidence, we evaluated whether cerebral hemodynamic changes contribute to post-COVID syndrome (PCS). Methods: Using resting-state functional magnetic resonance imaging, we investigated brain perfusion and oxygen level estimates in 47 patients (44.4 +/- 11.6 years; F:M = 38:9) and 47 individually matched healthy control participants. Group differences were calculated using two-sample t-tests. Multivariable linear regression was used for associations of each regional perfusion and oxygen level measure with cognition and sleepiness measures. Exploratory hazard ratios were calculated for each brain metric with clinical measures.<br /> Results: Patients presented with high levels of fatigue (79%) and daytime sleepiness (45%). We found widespread decreased brain oxygen levels, most evident in the white matter (false discovery rate adjusted-p-value (p-(FDR)) = 0.038) and cortical grey matter (p-(FDR) = 0.015). Brain perfusion did not differ between patients and healthy participants. However, delayed patient caudate nucleus perfusion was associated with better executive function (p-(FDR) = 0.008). Delayed perfusion in the cortical grey matter and hippocampus were associated with a reduced risk of daytime sleepiness (hazard ratio (HR) = 0.07, p = 0.037 and HR = 0.06, p = 0.034). Decreased putamen oxygen levels were associated with a reduced risk of poor cognitive outcome (HR = 0.22, p = 0.019). Meanwhile, lower thalamic oxygen levels were associated with a higher risk of cognitive fatigue (HR = 6.29, p = 0.017). Interpretation: Our findings of lower regional brain blood oxygen levels suggest increased cerebral metabolism in PCS, which potentially holds a compensatory function. These hemodynamic changes were related to symptom severity, possibly representing metabolic adaptations.

Introduction: Uterus transplantation has revolutionized reproductive medicine for women with absolute uterine factor infertility, resulting in more than 40 reported successful live births worldwide to date. Small animal models are pivotal to refine this surgical and immunological challenging procedure aiming to enhance safety for both the mother and the child. Material and methods:We established a syngeneic bicornuate uterus transplantation model in young female Lewis rats. All surgical procedures were conducted by an experienced and skilled microsurgeon who organized the learning process into multiple structured steps. Animals underwent meticulous preoperative preparation and postoperative care. Transplant success was monitored by sequential biopsies, monitoring graft viability and documenting histological changes long-term. Results: Bicornuate uterus transplantation were successfully established achieving an over 70% graft survival rate with the passage of time. The bicornuate model demonstrated safety and feasibility, yielding outcomes comparable to the unicornuate model in terms of ischemia times and complications. Longitudinal biopsies were well-tolerated, enabling comprehensive monitoring throughout the study. Conclusions: Our novel bicornuate rat uterus transplantation model provides a distinctive opportunity for sequential biopsies at various intervals after transplantation and, therefore, comprehensive monitoring of graft health, viability, and identification of potential signs of rejection. Furthermore, this model allows for different interventions in each horn for comparative studies without interobserver differences contrary to the established unicornuate model. By closely replicating the clinical setting, this model stands as a valuable tool for ongoing research in the field of uterus transplantation, promoting further innovation and deeper insights into the intricacies of the uterus transplant procedure.

Background: An innovation to better manage cat-allergic patients utilises anti-Fel d 1 IgY antibodies to neutralise Fel d 1 after its production by the cat. However, there is no published study showing its clinical efficacy in humans in a home setting. A longitudinal, open-label, proof-of-concept study was carried out to approach clinical efficacy of the cat food in cat-allergic patients. Methods: After a baseline evaluation, the cats ate only the cat food for the following 4 months. Daily evaluation of efficacy was performed for 2 weeks at baseline and after 1, 2 and 3 months of intervention for periods of 2 weeks. The MASK-air app was used daily to assess symptoms, work productivity and medications. Results: Of the 49 patients screened, 42 were followed up and 33 (78.5%) reported MASK-air data at all 3 evaluation periods. The primary end point (visual analogue scale [VAS] for global allergy symptoms) was significantly improved (p < 0.0001). All symptoms (VAS nose, eye, and asthma), VAS work and the combined symptom-medication score significantly improved after 1 month. The percentage of uncontrolled days (VAS>20/100) decreased from 64% at baseline to 35% at 1 month (p < 0.0001) and 14% at 3 months. A sensitivity analysis in patients with uncontrolled disease at baseline found similar results. Discussion: A cat diet containing anti-Fel d 1 antibodies was able to (i) show decreased allergic symptoms and related outcomes, (ii) inform the design and feasibility of future studies with a control arm and (iii) estimate the sample size of the study.

Background and aims: Intrahepatic cholangiocarcinoma (iCC) is an aggressive tumor, usually detected at an advanced stage. Our aim was to investigate the potential of body composition analysis (BCA) derived from presurgical staging computed tomography (CT) in predicting perisurgical complications. Methods: In this retrospective cohort study, we enrolled 86 patients who underwent CT imaging prior to liver surgery. Cox and logistic regression were performed to assess risk factors for prolonged hospital and intensive care unit (ICU) stays, as well as the occurrence of various complications. BCA parameters served as covariates besides conventional risk factors. Results: Postoperative complications after resection of iCC significantly prolonged the overall length of hospitalization (p < .001). Presence of sarcopenia was associated with longer ICU stays. Complications were common, with 62.5% classified as Clavien-Dindo grade IIIa or lower and 37.5% as more severe. Subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were identified as risk factors for complications, including bile leakage (in 24 cases, p = .025), pleural effusions (in 26 cases, p = .025), and intra-abdominal abscess formation (in 24 cases, p = .043). SAT was associated with severe complications requiring interventional therapy, whereas VAT was correlated with abscess formation. Despite normal prevalence of obesity (22%), body mass index (BMI) did not have an impact on the development of perioperative complications. Conclusion: BCA is a useful tool for preoperative risk stratification in patients with iCC and is superior to BMI assessment. Increased SAT and VAT were associated with the risk of perisurgical complications, prolonging hospitalization. Therefore, BCA derived from routine staging CT should be considered in the preoperative assessment of patients with iCC.

Background: Asthma presents a significant health challenge, imposing a considerable burden on healthcare services. Discrepancies in asthma-related hospitalisations may reflect underlying health disparities. We aimed to analyse inequities in asthma hospital admissions in mainland Portugal and Spain, from a regional perspective and considering sex and age. Methods: We conducted a retrospective study using data from the Spanish and Portuguese national hospitalisations databases. We calculated crude national and regional yearly hospitalisation rates according per Nomenclature of Territorial Units for Statistics region. Additionally, we calculated hospitalisation rates adjusted for asthma prevalence and the female-to-male ratio in asthma hospital admissions per age group, considering the female-to-male ratio in the overall population. Results: Between 2012 and 2016, there were 92,084 asthma hospital admissions in mainland Spain and 7717 in mainland Portugal. There was a trend for a higher-than-average rate of asthma-related hospitalisations in the Northern regions of both countries. Women had a hospitalisation rate that was 3.2 times higher than men. Age was associated with higher risk for asthma hospitalisation, with individuals aged 65 and older displaying a hospitalisation rate 4.5 times higher than those under 65. Additionally, while hospitalisations in women aged <65 years were 2.3 times more likely than in men of the same age, hospitalisations in women aged >= 65 years were 3.5 times higher than in men aged >= 65 years. Conclusion: This study suggests that marked regional inequities in asthma hospital admissions exist in Spain and Portugal. Additionally, women are particularly at risk of hospitalisation due to asthma, and such risk increases with age.

Background: Regular and consistent disease assessment could provide a clearer picture of burden in generalised myasthenia gravis (gMG) and improve patient care; however, the use of assessment tools in practice lacks standardisation. This modified Delphi approach was taken to review current evidence on assessment tool use in gMG and develop expert-derived consensus recommendations for good practice. Methods: A European expert panel of 15 experienced gMG neurologists contributed to development of this consensus, four of whom formed a lead Sub-committee. The PICO (Population, Intervention, Control, Outcomes) framework was used to define six clinical questions on gMG assessment tools, a systematic literature review was conducted, and evidence-based statements were developed. According to a modified Delphi voting process, consensus was reached when >= 70% of the experts rated agreement with a statement as >= 8 on a scale of 1-10. Results: Eighteen expert- and evidence-based consensus statements based on six themes were developed. Key recommendations include: consistent use of the Myasthenia Gravis Activities of Daily Living score (MG-ADL) across clinical settings, followed by a simple question (e.g., Patient Acceptable Symptom State [PASS]) or scale to determine patient satisfaction in clinical practice; use of a Quantitative Myasthenia Gravis [QMG] or quality of life [QoL] assessment when the MG-ADL indicates disease worsening; and consideration of symptom state to determine the timing and frequency of recommended assessments. Expert panel consensus was reached on all 18 statements after two voting rounds. Conclusions: This process provided evidence- and expert consensus-based recommendations for the use of objective and subjective assessment tools across gMG research and care to improve management and outcomes for patients.

In ancient Egypt, animals were an integral part of religious practices from the Predynastic Period onwards, with their symbolic and physical roles evolving over time. Various animal taxa associated with Egyptian deities were mummified and then placed in animal necropoleis and tombs across various locations. The ancient Egyptian animal cult has occupied Egyptologists and scientists from neighbouring disciplines since the 19th century. An overall negative assessment resulted in the subject being rather scientifically downplayed in the 19th and early 20th centuries, but has since given way to a growing interest in this subject. Nevertheless, questions remain still unanswered. There are clear deficits in the area of the re-contextualisation of once interrelated material remains and the associated possible re-evaluation. In a cooperation with the Ancient Orient Museum, Tokyo, an international workshop on the theme will be held in Japan from 28th to 30th July 2025.

The accessory carpal bone (ACB) is an important component of the equine carpus and a clinically relevant site of fracture, yet its detailed morphology and motion characteristics remain incompletely characterized. The objectives of this ex vivo study were to characterize the three-dimensional morphometry of the native ACB using computed tomography (CT), to assess its kinematics during carpal flexion and extension using dynamic 3D CT, and to evaluate fragment behavior following a standardized vertical fracture. Twelve equine forelimbs underwent CT imaging in the neutral carpal position, maximal flexion, and maximal extension before and after standardized osteotomy simulating a vertical plane fracture. Morphometric measurements included dorsopalmar width, lateromedial thickness, proximodistal length, and radii of medial concavity and lateral convexity. The ACB exhibited consistent geometry among specimens of comparable size. Dynamic imaging revealed independent physiological motion relative to the other carpal bones of the ACB, characterized by medial movement of its medial concave surface toward the caudal aspect of the radius during flexion. Following fracture creation, widening of the fracture gap and proximal displacement of the palmar fragment occurred predominantly in flexion, whereas the neutral carpal position and maximal extension promoted fracture gap closure and distal displacement. These findings improve understanding of ACB morphology and biomechanics and may have implications for fracture pathogenesis and surgical fixation strategies.

Invasive candidiasis is a fungal infection characterized by a high mortality rate. Carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family receptors play a crucial role in regulating innate responses of both leukocytes and epithelia. Human CEACAM3, CEACAM5 and CEACAM6 receptors recognize Candida albicans and are expressed in transgenic CEABAC10 mice. In a murine C. albicans infection model, CEABAC10 mice exhibited a shortened survival period attributed to an early cytokine storm, an exacerbated acute phase response, and heightened systemic inflammation compared to their wild-type littermates. The livers and kidneys of CEABAC10 mice displayed intensified purulent necrotizing inflammation, accompanied by increased infiltration of neutrophils and macrophages. Our in vivo and in vitro data indicated that the expression of CEACAM6 on monocytes of CEABAC10 mice caused the elevated cytokine levels and the subsequent exacerbation of the acute phase response upon C. albicans infection, resulting in decreased survival.

A two-cohort feasibility study was conducted to investigate the potential role of homeopathic therapy in reducing antimicrobial use in turkeys. The objective of the analysis presented here was to describe the complex characteristics of the study farms. For analysis of heterogeneity, data of 25 turkey farms (7 homeopathy (H); 18 conventional (C)) were analyzed. Farms in cohort H had significantly higher numbers of poultry farms nearby and included outdoor husbandry, while those in cohort C included neither organic nor biodynamic husbandry types. During raising, a combination of straw and wood shavings was more frequent, while during fattening, only one type of litter was predominant. Very few additional significant differences were identified at farm level, while at production batch level, several further differences existed. When comparing the study cohort characteristics with national statistics, both cohorts seemed to perform better than the national average. The incidence of antibiotic treatment days was lower in cohort H compared to cohort C (C 0.14, H 0.01, p < 0.001), while production period-related mortality (C 3.7%, H 3.7%) was comparable. Our detailed collection of data, previously unavailable, provides a relevant insight and will enable the analysis of multivariable aspects linked to antimicrobial usage in turkey production.

Streptococcus canis is an opportunistic pathogen that colonises the mucosal surfaces and skin of its host. Though predominantly a veterinary pathogen affecting cats and dogs, S. canis has also been identified as the causative agent in severe human disease. IdeC is a secreted cysteine protease of S. canis that has a high specificity for IgG, cleaving at the hinge region. We show here that the protein binds back to the surface of the bacteria. Additionally, the protein contains a conserved Arg-Gly-Asp (RGD) motif, the minimal peptide sequence required for integrin binding. Several bacterial proteins containing RGD motifs have been implicated in adhesion and invasion of host cells. This RGD motif along with the ability of IdeC to bind back to the bacterial surface after secretion is the basis for this study into a potential secondary function of IdeC in adhesion and/or invasion. We used protein-coated latex beads to investigate the interaction of IdeC with epithelial and endothelial cells and, further, the extent to which the RGD motif is involved in this interaction by utilising an RGD->RGE recombinant protein. We also report here that the deletion of IdeC in S. canis results in a significant reduction in invasion into epithelial cells.

The manual handling of poultry is an essential part of raising and caring for birds. The different manual catching methods have various impacts on the bird’s welfare and health, the well-being and work satisfaction of the people who are handling the birds, and the economic and logistical requirements of everyone involved. The traditional approach of using the Five Freedoms for investigating animal well-being has been amended with animal-based measures (ABMs) as well as the evaluation of five welfare domains, which consider the subjective response of an animal towards its environment. The assessment of single individual animal welfare parameters without context can be non-specific, only partially informative, or even misleading when considered in isolation. The objective measurement of suitable parameters for the evaluation of the various steps of poultry catching and transport is complex and should be carried out in a differentiated manner. This review summarizes the current knowledge about the manual catching of poultry, with special focus on the upright and inverted handling of chicken and current considerations in Europe. The implementation of consistent, transparent, and traceable central data collection on animal health and welfare at various critical control points of bird transportation would allow systematic evaluation of the multifactorial welfare assessment in the future.

Holonomic quantum computation exploits the geometric evolution of eigenspaces of a degenerate Hamiltonian to implement unitary evolution of computational states. In this work we introduce a framework for performing scalable quantum computation in atom experiments through a universal set of fully holonomic adiabatic gates. Through a detailed differential geometric analysis, we elucidate the geometric nature of these gates and their inherent robustness against classical control errors and other noise sources. The concepts that we introduce here are expected to be widely applicable to the understanding and design of error robustness in generic holonomic protocols. To underscore the practical feasibility of our approach, we contextualize our gate design within recent advancements in Rydberg-based quantum computing and simulation.

Excessive alcohol consumption among young people is a major public health concern. On March 1, 2010, the German state of Baden-Württemberg banned the sale of alcoholic beverages between 10pm and 5am at off-premise outlets (e.g., gas stations, kiosks, supermarkets). We use rich monthly administrative data from a 70 percent random sample of all hospitalizations during the years 2007-2011 in Germany in order to evaluate the short-term impact of this policy on alcohol-related hospitalizations. Applying difference-in-differences methods, we find that the policy change reduces alcohol-related hospitalizations among adolescents and young adults by about seven percent. There is also evidence of a decrease in the number of hospitalizations due to violent assault as a result of the ban.

Background and Aims: Skin aging is associated with dry skin and a decrease of the strength of the dermoepidermal adhesion, which increases the risk for lacerations (skin tears). Application of leave-on products improves dry skin and seems to reduce skin tear incidence. The aim of this study was to measure the effects of a humectant containing leave-on product on the strength of the dermoepidermal junction in older adult participants with dry skin. Methods: A randomized controlled trial using a split body design was conducted. One forearm was randomly selected and treated with a lipophilic leave-on product containing 5% urea for 8 weeks. The other forearm was the control. The parameters stratum corneum hydration (SCH), transepidermal water loss, pH, roughness, epidermal thickness and skin stiffness were measured at the baseline, Weeks 4 and 8. At Week 8, suction blisters were created and time to blistering was measured. Blister roofs and interstitial fluid were analyzed for Interleukin-1 alpha, 6 and 8. Results: Twelve participants were included. After 8 weeks treatment, SCH was higher (median difference 11.6 AU), and the overall dry skin score (median difference -1) and median roughness (Rz difference -12.2 mu m) were lower compared to the control arms. The median group difference for Interleukin-1 alpha was -452 fg/mu g total protein (TP) in the blister roofs and -2.2 fg/mu g TP in the blister fluids. The median time to blister formation was 7.7 min higher compared to the control arms. Conclusion: The regular application of humectant containing leave-on products improves dry skin and seems to lower inflammation and contribute to the strengthening of the dermoepidermal adhesion. This partly explains how the use of topical leave-on products helps to prevent skin tears.

We examine the consequences of compressing secondary schooling on university enrollment. An unusual education reform in Germany reduced the length of academic high school while simultaneously increasing the instruction hours in the remaining years. Accordingly, students receive the same amount of schooling but over a shorter period of time, constituting an efficiency gain from an individual’s perspective. Based on a differencein- differences approach and using administrative data on all students in Germany, we find that this reform decreased university enrollment rates. Moreover, students are more likely to delay their enrollment, to drop out of university, and to change their major. We discuss supply side restrictions, age differences, and increased workload during school as potential mechanisms and present back-of-the-envelope cost-benefit considerations showing that the earnings gain from an extended