dc.contributor.author
Graef, Josefine
dc.contributor.author
Senger, Carolin
dc.contributor.author
Wetz, Christoph
dc.contributor.author
Baur, Alexander D. J.
dc.contributor.author
Kluge, Anne K.
dc.contributor.author
Lukas, Mathias
dc.contributor.author
Rogasch, Julian M. M.
dc.contributor.author
Walter-Rittel, Thula C.
dc.contributor.author
Kohnert, David
dc.contributor.author
Makowski, Marcus
dc.contributor.author
Acker, Güliz
dc.contributor.author
Huang, Kai
dc.contributor.author
Budach, Volker
dc.contributor.author
Amthauer, Holger
dc.contributor.author
Schatka, Imke
dc.contributor.author
Furth, Christian
dc.date.accessioned
2021-02-09T11:52:57Z
dc.date.available
2021-02-09T11:52:57Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/29565
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-29309
dc.description.abstract
Ga-68-DOTATOC-PET/MRI can affect the planning target volume (PTV) definition of meningiomas before radiosurgery. A shorter tracer uptake time before image acquisition could allow the examination of more patients. The aim of this study was to investigate if shortening uptake time is possible without compromising diagnostic accuracy and PET volume. Fifteen patients (f = 12; mean age 52 years (34-80 years)) with meningiomas were prospectively examined with dynamic [68Ga]Ga-68-labeled [DOTA0-Phe1-Tyr3] octreotide (Ga-68-DOTATOC)-PET/MRI over 70 min before radiosurgery planning. Meningiomas were delineated manually in the PET dataset. PET volumes at each time point were compared to the reference standard 60 min post tracer injection (p.i.) using the Friedman test followed by a Wilcoxon signed-rank test and Bonferroni correction. In all patients, the earliest time point with 100% lesion detection compared to 60 min p.i. was identified. PET volumes did not change significantly from 15 min p.i. (p = 1.0) compared to 60 min p.i. The earliest time point with 100% lesion detection in all patients was 10 min p.i. In patients with meningiomas undergoing Ga-68-DOTATOC-PET, the tracer uptake time can safely be reduced to 15 min p.i. with comparable PET volume and 100% lesion detection compared to 60 min p.i.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
radiosurgery
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Shortened Tracer Uptake Time in GA-68-DOTATOC-PET of Meningiomas Does Not Impair Diagnostic Accuracy and PET Volume Definition
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1084
dcterms.bibliographicCitation.doi
10.3390/diagnostics10121084
dcterms.bibliographicCitation.journaltitle
Diagnostics
dcterms.bibliographicCitation.number
12
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
10
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33322125
dcterms.isPartOf.eissn
2075-4418