dc.contributor.author
Bröer, Sonja
dc.date.accessioned
2021-02-09T07:15:58Z
dc.date.available
2021-02-09T07:15:58Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/29557
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-29301
dc.description.abstract
The most researched brain region in epilepsy research is the temporal lobe, and more specifically, the hippocampus. However, numerous other brain regions play a pivotal role in seizure circuitry and secondary generalization of epileptic activity: The substantia nigra pars reticulata (SNr) and its direct input structure, the subthalamic nucleus (STN), are considered seizure gating nuclei. There is ample evidence that direct inhibition of the SNr is capable of suppressing various seizure types in experimental models. Similarly, inhibition via its monosynaptic glutamatergic input, the STN, can decrease seizure susceptibility as well. This review will focus on therapeutic interventions such as electrical stimulation and targeted drug delivery to SNr and STN in human patients and experimental animal models of epilepsy, highlighting the opportunities for overcoming pharmacoresistance in epilepsy by investigating these promising target structures.
en
dc.format.extent
11 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
basal ganglia
en
dc.subject
subthalamic nucleus (STN)
en
dc.subject
substantia nigra (SN)
en
dc.subject
focal therapy
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik
dc.title
Not Part of the Temporal Lobe, but Still of Importance? Substantia Nigra and Subthalamic Nucleus in Epilepsy
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
581826
dcterms.bibliographicCitation.doi
10.3389/fnsys.2020.581826
dcterms.bibliographicCitation.journaltitle
Frontiers in Systems Neuroscience
dcterms.bibliographicCitation.volume
14
dcterms.bibliographicCitation.url
https://doi.org/10.3389/fnsys.2020.581826
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Pharmakologie und Toxikologie

refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1662-5137
refubium.resourceType.provider
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