dc.contributor.author
Bock, Christopher
dc.contributor.author
Vogt, Birgit
dc.contributor.author
Mattecka, Stephan
dc.contributor.author
Yapici, Gülcan
dc.contributor.author
Brunner, Patrizia
dc.contributor.author
Fimpel, Sandra
dc.contributor.author
Unger, Juliane K.
dc.contributor.author
Sheriff, Ahmed
dc.date.accessioned
2021-02-01T12:23:52Z
dc.date.available
2021-02-01T12:23:52Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/29433
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-29179
dc.description.abstract
Systemic diseases characterized by elevated levels of C-reactive protein (CRP), such as sepsis or systemic inflammatory response syndrome, are usually associated with hardly controllable haemodynamic instability. We therefore investigated whether CRP itself influences blood pressure and heart rate. Immediately after intravenous injection of purified human CRP (3.5 mg CRP/kg body weight) into anesthetized rabbits, blood pressure dropped critically in all animals, while control animals injected with bovine serum albumin showed no response. Heart rate did not change in either group. Approaching this impact on a cellular level, we investigated the effect of CRP in cell lines expressing adrenoceptors (CHO-α1A and DU-145). CRP caused a Ca(2+)signaling being dependent on the CRP dose. After complete activation of the adrenoceptors by agonists, CRP caused additional intracellular Ca(2+)mobilization. We assume that CRP interacts with hitherto unknown structures on the surface of vital cells and thus interferes with the desensitization of adrenoceptors.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
cardiovascular system
en
dc.subject
adrenergic receptor
en
dc.subject
calcium transient
en
dc.subject
calcium signaling
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
C-Reactive Protein Causes Blood Pressure Drop in Rabbits and Induces Intracellular Calcium Signaling
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1978
dcterms.bibliographicCitation.doi
10.3389/fimmu.2020.01978
dcterms.bibliographicCitation.journaltitle
Frontiers in Immunology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
11
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32983135
dcterms.isPartOf.eissn
1664-3224