dc.contributor.author
Loosen, Sven H.
dc.contributor.author
Wirtz, Theresa H.
dc.contributor.author
Roy, Sanchari
dc.contributor.author
Vucur, Mihael
dc.contributor.author
Castoldi, Mirco
dc.contributor.author
Schneider, Anne T.
dc.contributor.author
Koppe, Christiane
dc.contributor.author
Ulmer, Tom F.
dc.contributor.author
Roeth, Anjali A.
dc.contributor.author
Bednarsch, Jan
dc.contributor.author
Alizai, Patrick H.
dc.contributor.author
Paffenholz, Pia
dc.contributor.author
Demir, Münevver
dc.contributor.author
Trautwein, Christian
dc.contributor.author
Tacke, Frank
dc.contributor.author
Neumann, Ulf P.
dc.contributor.author
Roderburg, Christoph
dc.contributor.author
Luedde, Tom
dc.date.accessioned
2020-11-24T09:26:22Z
dc.date.available
2020-11-24T09:26:22Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/28918
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-28667
dc.description.abstract
While tumor resection and liver transplantation (LT) represent potentially curative therapeutic options for patients with early-stage hepatocellular carcinoma (HCC), the identification of the ideal surgical candidates has remained challenging. Just recently, miRNA-193a-5p was described as a tumor suppressor in murine and human HCC but only little is known about circulating miRNA-193a-5p in HCC patients. Here, we evaluated serum levels of miR-193a-5p by qPCR in 41 HCC patients undergoing tumor resection (n = 33) or LT (n = 8) and 20 controls. Circulating relative miR-193a-5p levels were significantly elevated in HCC patients compared to healthy controls. While relative miR-193a-5p levels were comparable between patients of different underlying disease etiology and tumor size, high relative miR-193a-5p levels were predictive for the patients’ postoperative outcome, which was confirmed in uni- and multivariate Cox-regression analysis. As such, HCC patients with a preoperative relative miR-193a-5p level above the ideal cut-off value (3.57) had a median overall survival (OS) of only 451 days compared to 1158 days in patients with a relative miR-193a-5p level below this cut-off value. Our data support a novel function of miR-193a-5p as a biomarker in early-stage HCC patients that might help to identify the best surgical candidates in terms of postoperative outcome.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Area Under Curve
en
dc.subject
Case-Control Studies
en
dc.subject
Liver Neoplasms
en
dc.subject
Neoplasm Staging
en
dc.subject
Proportional Hazards Models
en
dc.subject
Survival Rate
en
dc.subject
Up-Regulation
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Circulating levels of microRNA193a-5p predict outcome in early stage hepatocellular carcinoma
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e0239386
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0239386
dcterms.bibliographicCitation.journaltitle
PLOS ONE
dcterms.bibliographicCitation.number
9
dcterms.bibliographicCitation.originalpublishername
Public Library of Science (PLoS)
dcterms.bibliographicCitation.volume
15
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32960907
dcterms.isPartOf.eissn
1932-6203