dc.contributor.author
Parmanand
dc.contributor.author
Mittal, Ayushi
dc.contributor.author
Singh, Abhishek K.
dc.contributor.author
Aarti
dc.contributor.author
Achazi, Katharina
dc.contributor.author
Nie, Chuanxiong
dc.contributor.author
Haag, Rainer
dc.contributor.author
Sharma, Sunil K.
dc.date.accessioned
2020-11-16T07:40:17Z
dc.date.available
2020-11-16T07:40:17Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/28863
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-28612
dc.description.abstract
A new class of non-ionic amphiphiles is synthesized using a diaryl derivative of diglycerol as a central core and functionalizing it with long alkyl chains (C-12/C-15) and monomethoxy PEG moiety (M-n: 350/550) by following a chemo-enzymatic approach. The aggregation behavior of the amphiphiles in aqueous medium is studied by using dynamic light scattering (DLS) and fluorescence spectroscopy, whereas the size and morphology of the aggregates are studied by transmission electron microscopy (TEM). A hydrophobic dye, Nile red and a hydrophobic drug, nimodipine, are used to demonstrate the nano-carrier capability of these non-ionic amphiphilic systems and the results are compared with amphiphilic analogues obtained from the triaryl derivatives of triglycerol. Thein vitrocontrolled release of the encapsulated dye is successfully carried out in the presence of immobilized Candida antarcticalipase (Novozym 435). Furthermore, cytotoxicity data is also collected which suggests that the amphiphiles are suitable for biomedical applications.
en
dc.format.extent
9 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
polymer therapeutics
en
dc.subject
building-blocks
en
dc.subject
nanoparticles
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
Oligo-glycerol based non-ionic amphiphilic nanocarriers for lipase mediated controlled drug release
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1039/D0RA07392J
dcterms.bibliographicCitation.journaltitle
RSC Advances
dcterms.bibliographicCitation.number
61
dcterms.bibliographicCitation.pagestart
37555
dcterms.bibliographicCitation.pageend
37563
dcterms.bibliographicCitation.volume
10
dcterms.bibliographicCitation.url
https://doi.org/10.1039/D0RA07392J
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2046-2069
refubium.resourceType.provider
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