dc.contributor.author
Plage, Henning
dc.contributor.author
Pielka, Poline
dc.contributor.author
Liefeldt, Lutz
dc.contributor.author
Budde, Klemens
dc.contributor.author
Ebbing, Jan
dc.contributor.author
Sugünes, Nesrin
dc.contributor.author
Miller, Kurt
dc.contributor.author
Cash, Hannes
dc.contributor.author
Bichmann, Anna
dc.contributor.author
Sattler, Arne
dc.contributor.author
Kotsch, Katja
dc.contributor.author
Friedersdorff, Frank
dc.date.accessioned
2021-01-13T13:39:47Z
dc.date.available
2021-01-13T13:39:47Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/28753
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-28501
dc.description.abstract
Purpose: An expansion of selection criteria for deceased organ transplantation already exists to manage the current donor shortage. Comparable evaluation of risk factors for living donors should be investigated to improve this issue.
Patients and methods: Our retrospective single-centre study analysed 158 patients with living kidney transplants performed between February 2006 and June 2012. We investigated the influence of donor risk factors (RF) including body mass index over 30 kg/m2, age >60 years, active nicotine abuse and arterial hypertension on postoperative kidney function with focus on the recipients. This was measured for long-term survival and glomerular filtration rate (GFR) in a 5-year follow-up.
Results: Overall, out of 158 living donors, 84 donors were identified to have no risk factors, whereas 74 donors had at least one risk factor. We noted a significant higher delayed graft function (p=0.042) in the first 7 days after transplantation, as well as lower GFR of recipients of allografts with risk factors in the first-year after transplantation. In our long-term results, there was no significant difference in the functional outcome (graft function, recipient and graft survival) between recipients receiving kidneys from donors with no and at least one risk factors. In the adjusted analysis of subgroups of different risk factors, recipients of donors with "age over 60 years" at time of transplantation had a decreased transplant survival (p=0.014).
Conclusion: Thus, a careful expansion for selection criteria for living donors with critical evaluation could be possible, but especially the age of the donors could be a limited risk factor.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
living donor nephrectomy
en
dc.subject
selection criteria
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Extended Criteria Donors in Living Kidney Transplantation Including Donor Age, Smoking, Hypertension and BMI
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.2147/TCRM.S256962
dcterms.bibliographicCitation.journaltitle
Therapeutics and Clinical Risk Management
dcterms.bibliographicCitation.originalpublishername
Dove Medical Press
dcterms.bibliographicCitation.pagestart
787
dcterms.bibliographicCitation.pageend
793
dcterms.bibliographicCitation.volume
16
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32922016
dcterms.isPartOf.eissn
1178-203X