dc.contributor.author
Golde, Sabrina
dc.contributor.author
Heine, Josephine
dc.contributor.author
Pöttgen, Jana
dc.contributor.author
Mantwill, Maron
dc.contributor.author
Lau, Stephanie
dc.contributor.author
Wingenfeld, Katja
dc.contributor.author
Otte, Christian
dc.contributor.author
Penner, Iris-Katharina
dc.contributor.author
Engel, Andreas K.
dc.contributor.author
Heesen, Christoph
dc.contributor.author
Stellmann, Jan-Patrick
dc.contributor.author
Dziobek, Isabel
dc.contributor.author
Finke, Carsten
dc.contributor.author
Gold, Stefan M.
dc.date.accessioned
2020-09-23T15:36:38Z
dc.date.available
2020-09-23T15:36:38Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/28353
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-28103
dc.description.abstract
Objective: Multiple sclerosis (MS) is characterized by impairments in basic cognitive functions such as information processing speed as well as in more complex, higher-order domains such as social cognition. However, as these deficits often co-occur, it has remained challenging to determine whether they have a specific pathological basis or are driven by shared biology. Methods: To identify neural signatures of social cognition deficits in MS, data were analyzed from n = 29 patients with relapsing-remitting MS and n = 29 healthy controls matched for age, sex, and education. We used neuropsychological assessments of information processing speed, attention, learning, working memory, and relevant aspects of social cognition (theory of mind, emotion recognition (ER), empathy) and employed neuroimaging of CNS networks using resting-state functional connectivity. Results: MS patients showed significant deficits in verbal learning and memory, as well as implicit ER. Performance in these domains was uncorrelated. Functional connectivity analysis identified a distinct network characterized by significant associations between poorer ER and lower connectivity of the fusiform gyrus (FFG) with the right lateral occipital cortex, which also showed lower connectivity in patients compared to controls. Moreover, while ER was correlated with MS symptoms such as fatigue and motor/sensory functioning on a behavioral level, FFG connectivity signatures of social cognition deficits showed no overlap with these symptoms. Conclusions: Our analyses identify distinct functional connectivity signatures of social cognition deficits in MS, indicating that these alterations may occur independently from those in other neuropsychological functions.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
multiple sclerosis
en
dc.subject
social cognition
en
dc.subject
functional connectivity
en
dc.subject
emotion recognition
en
dc.subject
fusiform gyrus
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Distinct Functional Connectivity Signatures of Impaired Social Cognition in Multiple Sclerosis
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
507
dcterms.bibliographicCitation.doi
10.3389/fneur.2020.00507
dcterms.bibliographicCitation.journaltitle
Frontiers in Neurology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media S.A.
dcterms.bibliographicCitation.volume
11
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32670178
dcterms.isPartOf.eissn
1664-2295