dc.contributor.author
Hamann, Lutz
dc.contributor.author
Szwed, Malgorzata
dc.contributor.author
Mossakowska, Malgorzata
dc.contributor.author
Chudek, Jerzy
dc.contributor.author
Puzianowska-Kuznicka, Monika
dc.date.accessioned
2020-09-23T12:02:33Z
dc.date.available
2020-09-23T12:02:33Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/28251
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-28001
dc.description.abstract
Obesity is a risk factor for several aging-related diseases such as type 2 diabetes, cardiovascular disease, and cancer. Especially, cardiovascular disease is triggered by obesity by inducing vascular senescence and chronic low-grade systemic inflammation, also known as inflamm-aging. Released molecules from damaged cells and their recognition by the innate immune system is one of the mechanisms driving inflamm-aging. Obesity results in mitochondrial damage, leading to endothelial inflammation triggered by cytosolic mtDNA via the cGAS/STING pathway. Recently, we have shown STING SNP R293Q to be associated with a decreased risk for aging-related diseases in current smokers. Since current smoking triggers DNA damage that, similar to obesity, may result in the release of DNA into the cytoplasm, we hypothesized that the cGAS/STING pathway can modify the phenotype of aging also in obese subjects. Therefore, the objective of our study was to investigate whether STING R293Q is associated with aging-related diseases in obese individuals. We indeed show that STING 293Q is associated with protection from combined aging-related diseases (P = 0.014) and, in particular, cardiovascular disease in these subjects (P = 0.010). Therefore, we provide the first evidence that stratification for obesity may reveal new genetic loci determining the risk for aging-related diseases.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Inflamm-aging
en
dc.subject
Polymorphism
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
First evidence for STING SNP R293Q being protective regarding obesity-associated cardiovascular disease in age-advanced subjects - a cohort study
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
7
dcterms.bibliographicCitation.doi
10.1186/s12979-020-00176-y
dcterms.bibliographicCitation.journaltitle
Immunity & Ageing
dcterms.bibliographicCitation.originalpublishername
BMC
dcterms.bibliographicCitation.volume
17
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32190093
dcterms.isPartOf.eissn
1742-4933