dc.contributor.author
Mishra, Santosh K.
dc.contributor.author
Wheeler, Joshua J.
dc.contributor.author
Pitake, Saumitra
dc.contributor.author
Ding, Huiping
dc.contributor.author
Jiang, Changyu
dc.contributor.author
Fukuyama, Tomoki
dc.contributor.author
Paps, Judy S.
dc.contributor.author
Ralph, Patrick
dc.contributor.author
Bäumer, Wolfgang
dc.date.accessioned
2020-09-10T09:21:43Z
dc.date.available
2020-09-10T09:21:43Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/28231
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-27981
dc.description.abstract
Chronic allergic itch is a common symptom affecting millions of people and animals, but its pathogenesis is not fully explained. Herein, we show that periostin, abundantly expressed in the skin of patients with atopic dermatitis (AD), induces itch in mice, dogs, and monkeys. We identify the integrin αVβ3 expressed on a subset of sensory neurons as the periostin receptor. Using pharmacological and genetic approaches, we inhibited the function of neuronal integrin αVβ3, which significantly reduces periostin-induced itch in mice. Furthermore, we show that the cytokine TSLP, the application of AD-causing MC903 (calcipotriol), and house dust mites all induce periostin secretion. Finally, we establish that the JAK/STAT pathway is a key regulator of periostin secretion in keratinocytes. Altogether, our results identify a TSLP-periostin reciprocal activation loop that links the skin to the spinal cord via peripheral sensory neurons, and we characterize the non-canonical functional role of an integrin in itch.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
atopic dermatitis
en
dc.subject
chronic allergic itch
en
dc.subject
keratinocytes
en
dc.subject
sensory neuron
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik
dc.title
Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
107472
dcterms.bibliographicCitation.doi
10.1016/j.celrep.2020.03.036
dcterms.bibliographicCitation.journaltitle
Cell Reports
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.volume
31
dcterms.bibliographicCitation.url
https://doi.org/10.1016/j.celrep.2020.03.036
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Pharmakologie und Toxikologie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2211-1247
dcterms.isPartOf.zdb
2649101-1