dc.contributor.author
Pieper, Robert
dc.contributor.author
Dadi, Temesgen H.
dc.contributor.author
Pieper, Laura
dc.contributor.author
Vahjen, Wilfried
dc.contributor.author
Franke, Andre
dc.contributor.author
Reinert, Knut
dc.contributor.author
Zentek, Jürgen
dc.date.accessioned
2020-10-15T13:05:42Z
dc.date.available
2020-10-15T13:05:42Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/28226
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-27976
dc.description.abstract
Despite a well-documented effect of high dietary zinc oxide on the pig intestinal microbiota composition less is it yet known about changes in microbial functional properties or the effect of organic zinc sources. Forty weaning piglets in four groups were fed diets supplemented with 40 or 110 ppm zinc as zinc oxide, 110 ppm as Zn-Lysinate, or 2500 ppm as zinc oxide. Host zinc homeostasis, intestinal zinc fractions, and ileal nutrient digestibility were determined as main nutritional and physiological factors putatively driving colon microbial ecology. Metagenomic sequencing of colon microbiota revealed only clear differences at genus level for the group receiving 2500 ppm zinc oxide. However, a clear group differentiation according to dietary zinc concentration and source was observed at species level. Functional analysis revealed significant differences in genes related to stress response, mineral, and carbohydrate metabolism. Taxonomic and functional gene differences were accompanied with clear effects in microbial metabolite concentration. Finally, a selection of certain antibiotic resistance genes by dietary zinc was observed. This study sheds further light onto the consequences of concentration and chemical form of dietary zinc on microbial ecology measures and the resistome in the porcine colon.
en
dc.format.extent
11 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
bacterial communities
en
dc.subject
organic forms
en
dc.subject
weaning pigs
en
dc.subject
bioavailability
en
dc.subject
accumulation
en
dc.subject
metallothionein
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
dc.title
Concentration and chemical form of dietary zinc shape the porcine colon microbiome, its functional capacity and antibiotic resistance gene repertoire
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1038/s41396-020-0730-3
dcterms.bibliographicCitation.journaltitle
The ISME Journal
dcterms.bibliographicCitation.pagestart
2783
dcterms.bibliographicCitation.pageend
2793
dcterms.bibliographicCitation.volume
14
dcterms.bibliographicCitation.url
https://doi.org/10.1038/s41396-020-0730-3
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Tierernährung

refubium.funding
Springer Nature DEAL
refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1751-7370
refubium.resourceType.provider
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