dc.contributor.author
Klehmet, Juliane
dc.contributor.author
Beutner, Svenja
dc.contributor.author
Hoffmann, Sarah
dc.contributor.author
Dornauer, Matthias
dc.contributor.author
Paul, Friedemann
dc.contributor.author
Reilmann, Ralf
dc.contributor.author
Brandt, Alexander U.
dc.contributor.author
Meisel, Andreas
dc.date.accessioned
2020-08-20T12:09:23Z
dc.date.available
2020-08-20T12:09:23Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/28064
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-27814
dc.description.abstract
Background: In patients suffering from Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) disease severity is assessed by Medical Research Counsil (MRC) Scale or Inflammatory Neuropathy Cause and Treatment (INCAT) disability score. However, none of these methods is appropriate to objectively assess muscle weakness or to detect very small subclinical changes. More objective and quantitative measures are needed in order to evaluate treatment efficiency or to detect subclinical affection of upper limps for early diagnosis. The goal of our study was to objectively quantify muscular weakness in CIDP patients with the non-invasive Quantitative Motor (Q-Motor) test of Grip Force Assessment (QGFA) as well as the Involuntary Movement Assessment (QIMA) and to search for differences between typical and atypical CIDP variants. In addition, we hypothesized that Q-Motor findings correlate with disease severity scales such as MRC or INCAT score.
Methods: In this cross-sectional exploratory proof-of-concept study subjects with confirmed diagnosis of typical or atypical CIDP were examined and compared to healthy controls (HC). For Q-Motor tests all subjects had to lift a device (250 g and 500 g) equipped with an electromagnetic sensor that measured grip force (GF) and three-dimensional changes in position and orientation. The measures "grip force variability" (GFV), "position index" (PI) and "orientation index" (OI) were provided to assess involuntary movements due to muscular weakness.
Results: 33 patients with CIDP and 28 HC were included. All measures were significantly elevated in CIDP patients for both devices in the right and left hand compared to healthy controls. Subgroup analysis revealed no differences between typical and atypical CIDP variants. INCAT score only weakly correlated with OI and PI. However, there was a stronger correlation between MRC and QIMA parameters in both hands.
Conclusion: Q-Motor assessments were capable to objectively assess muscular weakness in CIDP. In particular, QIMA measures detected subclinical generalized muscle weakness even in patients with milder disability. Sensitivity and rater-independence of Q-Motor assessments support a further exploration of QIMA measures as potential endpoints for future clinical trials in CIDP.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Clinical outcome parameter
en
dc.subject
CIDP subgroups
en
dc.subject
Case control studies
en
dc.subject
Diagnostic test assessment
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Quantitative grip force assessment of muscular weakness in chronic inflammatory demyelinating polyneuropathy
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
118
dcterms.bibliographicCitation.doi
10.1186/s12883-019-1339-x
dcterms.bibliographicCitation.journaltitle
BMC Neurology
dcterms.bibliographicCitation.originalpublishername
BMC
dcterms.bibliographicCitation.volume
19
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31176377
dcterms.isPartOf.eissn
1471-2377