dc.contributor.author
Maleitzke, Tazio
dc.contributor.author
Elazaly, Hisham
dc.contributor.author
Festbaum, Christian
dc.contributor.author
Eder, Christian
dc.contributor.author
Karczewski, Daniel
dc.contributor.author
Perka, Carsten
dc.contributor.author
Duda, Georg N.
dc.contributor.author
Winkler, Tobias
dc.date.accessioned
2020-09-08T10:34:01Z
dc.date.available
2020-09-08T10:34:01Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/27926
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-27679
dc.description.abstract
Osteoarthritis (OA) is the most common degenerative joint disorder worldwide and to date no regenerative treatment has been established in clinical practice. This review evaluates the current literature on the clinical translation of mesenchymal stromal cell (MSC)-based therapy in OA management with a focus on safety, outcomes and procedural specifics. PubMed, Cochrane Library and clinicaltrials.gov were searched for clinical studies using MSCs for OA treatment. 290 articles were initially identified and 42 articles of interest, including a total of 1325 patients, remained for further examination. Most of the included studies used adipose tissue-derived MSCs or bone-marrow-derived MSCs to treat patients suffering from knee OA. MSC-based therapy for knee OA appears to be safe and presumably effective in selected parameters. Yet, a direct comparison between studies was difficult due to a pronounced variance regarding methodology, assessed outcomes and evidence levels. Intensive scientific engagement is needed to identify the most effective source and dosage of MSCs for OA treatment in the future. Consent on outcome measures has to be reached and eventually patient sub-populations need to be identified that will profit most from MSC-based treatment for OA.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
mesenchymal stromal cell
en
dc.subject
osteoarthritis
en
dc.subject
regenerative therapy
en
dc.subject
cell-based therapy
en
dc.subject
degenerative joint disease
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Mesenchymal Stromal Cell-Based Therapy-An Alternative to Arthroplasty for the Treatment of Osteoarthritis? A State of the Art Review of Clinical Trials
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
2062
dcterms.bibliographicCitation.doi
10.3390/jcm9072062
dcterms.bibliographicCitation.journaltitle
Journal of Clinical Medicine
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
9
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32630066
dcterms.isPartOf.eissn
2077-0383