dc.contributor.author
Isert, Saskia
dc.contributor.author
Müller, Dominik
dc.contributor.author
Thumfart, Julia
dc.date.accessioned
2020-07-29T07:54:22Z
dc.date.available
2020-07-29T07:54:22Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/27880
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-27633
dc.description.abstract
Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of end-stage renal disease in children and adolescents. The diversity of the malformations summarized by CAKUT is high and there are numerous associated syndromes. The genetic background of these malformations remains unknown in the majority of cases. The aim of this study was to evaluate factors associated with the development of chronic kidney disease (CKD) and underlying genetic aberrations in children and adolescents with CAKUT. For this purpose, data from patients with CAKUT presented at the pediatric nephrology outpatient clinic were analyzed in a cross-sectional single-center study. Among the 405 patients, the commonest findings related to CAKUT were renal hypoplasia/dysplasia (65%), followed by hydronephrosis (43%). Forty-four percent of the patients were suffering from CKD, 6% were ranked as end-stage renal disease. In the univariate analysis, male gender and premature birth were associated with higher CKD stages (p = 0.004 resp. p < 0.001). Children with an abnormal prenatal ultrasound had more often a glomerular filtration rate of <30 ml/min/1.73 m2 (p = 0.004). Patients with urinary tract infections as first symptom whereas had significant lower CKD stages (p = 0,006). In the multivariate analysis, premature birth (p = 0.033) and urinary tract infection as the first symptom (p = 0.043) were significantly associated with CKD stage ≥ II. Among the 16% of the children who have undergone genetic analyses the most frequent genetic aberration was a mutation in HNF1β-gene. These results can be used for the care of patients with CAKUT subject to factors associated with developing CKD.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
chronic kidney disease
en
dc.subject
prenatal factors
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Factors Associated With the Development of Chronic Kidney Disease in Children With Congenital Anomalies of the Kidney and Urinary Tract
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
298
dcterms.bibliographicCitation.doi
10.3389/fped.2020.00298
dcterms.bibliographicCitation.journaltitle
Frontiers in Pediatrics
dcterms.bibliographicCitation.originalpublishername
Frontiers Media S.A.
dcterms.bibliographicCitation.volume
8
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32612963
dcterms.isPartOf.eissn
2296-2360