dc.contributor.author
Volkmann, Constantin
dc.contributor.author
Bschor, Tom
dc.contributor.author
Köhler, Stephan
dc.date.accessioned
2020-07-22T13:30:48Z
dc.date.available
2020-07-22T13:30:48Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/27866
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-27619
dc.description.abstract
Lithium has been the treatment of choice for patients with bipolar disorder (BD) for nearly 70 years. It is recommended by all relevant guidelines as a first-line treatment for maintenance therapy. In this review, we outline the current state of evidence for lithium in the treatment of BD over the lifespan. First, we summarize the evidence on efficacy in general, from relapse prevention to acute anti-manic treatment and its role in treating mood episodes with mixed features and bipolar depression. As patients are often treated for many years and different aspects have to be considered in different phases of life, we discuss the particularities of lithium in the treatment of paediatric BD, in older aged individuals and in pregnant women. Lastly, we discuss the evidence on lithium's proposed suicide-preventive effects, the dangers of rapid discontinuation and lithium's adverse effects, particularly with regard to long-term treatment.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
bipolar disorder
en
dc.subject
discontinuation
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Lithium Treatment Over the Lifespan in Bipolar Disorders
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
377
dcterms.bibliographicCitation.doi
10.3389/fpsyt.2020.00377
dcterms.bibliographicCitation.journaltitle
Frontiers in Psychiatry
dcterms.bibliographicCitation.originalpublishername
Frontiers Media S.A.
dcterms.bibliographicCitation.volume
11
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32457664
dcterms.isPartOf.eissn
1664-0640