dc.contributor.author
Ghorbani, Niky
dc.contributor.author
Muthurangu, Vivek
dc.contributor.author
Khushnood, Abbas
dc.contributor.author
Goubergrits, Leonid
dc.contributor.author
Nordmeyer, Sarah
dc.contributor.author
Fernandes, Joao Filipe
dc.contributor.author
Lee, Chong-Bin
dc.contributor.author
Runte, Kilian
dc.contributor.author
Roth, Sophie
dc.contributor.author
Schubert, Stephan
dc.contributor.author
Kelle, Sebastian
dc.contributor.author
Berger, Felix
dc.contributor.author
Kuehne, Titus
dc.contributor.author
Kelm, Marcus
dc.date.accessioned
2020-07-21T06:41:31Z
dc.date.available
2020-07-21T06:41:31Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/27859
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-27612
dc.description.abstract
Objective: We aimed to investigate the combined effects of arterial hypertension, bicuspid aortic valve disease (BAVD) and age on the distensibility of the ascending and descending aortas in patients with aortic coarctation.
Design: Cross-sectional study.
Setting: The study was conducted at two university medical centres, located in Berlin and London.
Participants: A total of 121 patients with aortic coarctation (ages 1-71 years) underwent cardiac MRI, echocardiography and blood pressure measurements.
Outcome measures: Cross-sectional diameters of the ascending and descending aortas were assessed to compute aortic area distensibility. Findings were compared with age-specific reference values. The study complied with the Strengthening the Reporting of Observational Studies in Epidemiology statement and reporting guidelines.
Results: Impaired distensibility (below fifth percentile) was seen in 37% of all patients with coarctation in the ascending aorta and in 43% in the descending aorta. BAVD (43%) and arterial hypertension (72%) were present across all ages. In patients >10 years distensibility impairment of the ascending aorta was predominantly associated with BAVD (OR 3.1, 95% CI 1.33 to 7.22, p=0.009). Distensibility impairment of the descending aorta was predominantly associated with arterial hypertension (OR 2.8, 95% CI 1.08 to 7.2, p=0.033) and was most pronounced in patients with uncontrolled hypertension despite antihypertensive treatment.
Conclusion: From early adolescence on, both arterial hypertension and BAVD have a major impact on aortic distensibility. Their specific effects differ in strength and localisation (descending vs ascending aorta). Moreover, adequate blood pressure control is associated with improved distensibility. These findings could contribute to the understanding of cardiovascular complications and the management of patients with aortic coarctation.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
hypertension
en
dc.subject
congenital heart disease
en
dc.subject
paediatric cardiology
en
dc.subject
valvular heart disease
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Impact of valve morphology, hypertension and age on aortic wall properties in patients with coarctation: a two-centre cross-sectional study
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e034853
dcterms.bibliographicCitation.doi
10.1136/bmjopen-2019-034853
dcterms.bibliographicCitation.journaltitle
BMJ Open
dcterms.bibliographicCitation.number
3
dcterms.bibliographicCitation.originalpublishername
BMJ Publishing Group
dcterms.bibliographicCitation.volume
10
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32213521
dcterms.isPartOf.eissn
2044-6055