dc.contributor.author
Hanitsch, Leif Gunnar
dc.contributor.author
Krüger, Renate
dc.contributor.author
Hoppe, Pia-Alice
dc.contributor.author
Humme, Daniel
dc.contributor.author
Pokrywka, Anna
dc.contributor.author
Niebank, Michaela
dc.contributor.author
Stegemann, Miriam
dc.contributor.author
Kola, Axel
dc.contributor.author
Leistner, Rasmus
dc.date.accessioned
2020-07-15T13:06:45Z
dc.date.available
2020-07-15T13:06:45Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/27764
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-27517
dc.description.abstract
Background: Recurrent skin abscesses are often associated with Panton-Valentine leukocidin-producing strains of S. aureus (PVL-SA). Decolonization measures are required along with treatment of active infections to prevent re-infection and spreading. Even though most PVL-SA patients are treated as outpatients, there are few studies that assess the effectiveness of outpatient topical decolonization in PVL-SA patients.
Methods: We assessed the results of topical decolonization of PVL-SA in a retrospective review of patient files and personal interviews. Successful decolonization was defined as the absence of any skin abscesses for at least 6 months after completion of the final decolonization treatment. Clinical and demographic data was assessed. An intention-to-treat protocol was used.
Results: Our cohort consisted of 115 symptomatic patients, 66% from PVL-positive MSSA and 19% from PVL-positive MRSA. The remaining 16% consisted of symptomatic patients with close contact to PVL-SA positive index patients but without detection of PVL-SA. The majority of patients were female (66%). The median age was 29.87% of the patients lived in multiple person households. Our results showed a 48% reduction in symptomatic PVL-SA cases after the first decolonization treatment. The results also showed that the decrease continued with each repeated decolonization treatment and reached 89% following the 5th treatment. A built multivariable Cox proportional-hazards model showed that the absence of PVL-SA detection (OR 2.0) and living in single person households (OR 2.4) were associated with an independently increased chance of successful decolonization.
Conclusion: In our cohort, topical decolonization was a successful preventive measure for reducing the risk of PVL-SA skin abscesses in the outpatient setting. Special attention should be given to patients living in multiple person households because these settings could confer a risk that decolonization will not be successful.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Panton-Valentine leukocidin (PVL)
en
dc.subject
Skin infection
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Outpatient decolonization after recurrent skin infection with Panton-Valentine leukocidin (PVL)-producing S. aureus - The importance of treatment repetition
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e0231772
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0231772
dcterms.bibliographicCitation.journaltitle
PLoS ONE
dcterms.bibliographicCitation.number
4
dcterms.bibliographicCitation.originalpublishername
Public Library of Science (PLoS)
dcterms.bibliographicCitation.volume
15
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32315364
dcterms.isPartOf.eissn
1932-6203