dc.contributor.author
Brüning, Jan
dc.contributor.author
Hildebrandt, Thomas
dc.contributor.author
Heppt, Werner
dc.contributor.author
Schmidt, Nora
dc.contributor.author
Lamecker, Hans
dc.contributor.author
Szengel, Angelika
dc.contributor.author
Amiridze, Natalja
dc.contributor.author
Ramm, Heiko
dc.contributor.author
Bindernagel, Matthias
dc.contributor.author
Zachow, Stefan
dc.contributor.author
Goubergrits, Leonid
dc.date.accessioned
2020-06-03T14:48:21Z
dc.date.available
2020-06-03T14:48:21Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/27419
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-27175
dc.description.abstract
This study’s objective was the generation of a standardized geometry of the healthy nasal cavity. An average geometry of the healthy nasal cavity was generated using a statistical shape model based on 25 symptom-free subjects. Airflow within the average geometry and these geometries was calculated using fluid simulations. Integral measures of the nasal resistance, wall shear stresses (WSS) and velocities were calculated as well as cross-sectional areas (CSA). Furthermore, individual WSS and static pressure distributions were mapped onto the average geometry. The average geometry featured an overall more regular shape that resulted in less resistance, reduced WSS and velocities compared to the median of the 25 geometries. Spatial distributions of WSS and pressure of the average geometry agreed well compared to the average distributions of all individual geometries. The minimal CSA of the average geometry was larger than the median of all individual geometries (83.4 vs. 74.7 mm²). The airflow observed within the average geometry of the healthy nasal cavity did not equal the average airflow of the individual geometries. While differences observed for integral measures were notable, the calculated values for the average geometry lay within the distributions of the individual parameters. Spatially resolved parameters differed less prominently.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Healthy Human Nasal Cavity
en
dc.subject
Wall Shear Stresses (WSS)
en
dc.subject
Cross-Sectional Areas (CSA)
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Characterization of the Airflow within an Average Geometry of the Healthy Human Nasal Cavity
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
3755
dcterms.bibliographicCitation.doi
10.1038/s41598-020-60755-3
dcterms.bibliographicCitation.journaltitle
Scientific Reports
dcterms.bibliographicCitation.originalpublishername
Nature Research
dcterms.bibliographicCitation.volume
10
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32111935
dcterms.isPartOf.eissn
2045-2322