dc.contributor.author
Blüthner, Elisabeth
dc.contributor.author
Pape, Ulrich-Frank
dc.contributor.author
Stockmann, Martin
dc.contributor.author
Karber, Mirjam
dc.contributor.author
Maasberg, Sebastian
dc.contributor.author
Pevny, Sophie
dc.contributor.author
Gerlach-Runge, Undine
dc.contributor.author
Pascher, Andreas
dc.contributor.author
Pratschke, Johann
dc.contributor.author
Tacke, Frank
dc.contributor.author
Bednarsch, Jan
dc.date.accessioned
2020-05-28T14:18:26Z
dc.date.available
2020-05-28T14:18:26Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/27417
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-27173
dc.description.abstract
Liver abnormalities in intestinal failure (IF) patients receiving parenteral nutrition (PN) can progress undetected by standard laboratory tests to intestinal failure associated liver disease (IFALD). The aim of this longitudinal study is to evaluate the ability of non-invasive liver function tests to assess liver function following the initiation of PN. Twenty adult patients with IF were prospectively included at PN initiation and received scheduled follow-up assessments after 6, 12, and 24 months between 2014 and 2019. Each visit included liver assessment (LiMAx [Liver Maximum Capacity] test, ICG [indocyanine green] test, FibroScan), laboratory tests (standard laboratory test, NAFLD [non-alcoholic fatty liver disease] score, FIB-4 [fibrosis-4] score), nutritional status (bioelectrical impedance analysis, indirect calorimetry), and quality of life assessment. The patients were categorized post-hoc based on their continuous need for PN into a reduced parenteral nutrition (RPN) group and a stable parenteral nutrition (SPN) group. While the SPN group (n = 9) had significantly shorter small bowel length and poorer nutritional status at baseline compared to the RPN group (n = 11), no difference in liver function was observed between the distinct groups. Over time, liver function determined by LiMAx did continuously decrease from baseline to 24 months in the SPN group but remained stable in the RPN group. This decrease in liver function assessed with LiMAx in the SPN group preceded deterioration of all other investigated liver function tests during the study period. Our results suggest that the liver function over time is primarily determined by the degree of intestinal failure. Furthermore, the LiMAx test appeared more sensitive in detecting early changes in liver function in comparison to other liver function tests.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
intestinal failure
en
dc.subject
intestinal failure associated liver disease
en
dc.subject
parenteral nutrition
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Assessing Non-Invasive Liver Function in Patients With Intestinal Failure Receiving Total Parenteral Nutrition-Results From the Prospective PNLiver Trial
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1217
dcterms.bibliographicCitation.doi
10.3390/nu12051217
dcterms.bibliographicCitation.journaltitle
Nutrients
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
12
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32357501
dcterms.isPartOf.eissn
2072-6643