dc.contributor.author
Kräker, Kristin
dc.contributor.author
Schütte, Till
dc.contributor.author
O’Driscoll, Jamie
dc.contributor.author
Birukov, Anna
dc.contributor.author
Patey, Olga
dc.contributor.author
Herse, Florian
dc.contributor.author
Müller, Dominik N.
dc.contributor.author
Thilaganathan, Basky
dc.contributor.author
Haase, Nadine
dc.contributor.author
Dechend, Ralf
dc.date.accessioned
2020-03-26T13:20:06Z
dc.date.available
2020-03-26T13:20:06Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/27033
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-26794
dc.description.abstract
Several studies have shown that women with a preeclamptic pregnancy exhibit an increased risk of cardiovascular disease. However, the underlying molecular mechanisms are unknown. Animal models are essential to investigate the causes of this increased risk and have the ability to assess possible preventive and therapeutic interventions. Using the latest technologies such as speckle tracking echocardiography (STE), it is feasible to map subclinical changes in cardiac diastolic and systolic function as well as structural changes of the maternal heart. The aim of this work is to compare cardiovascular changes in an established transgenic rat model with preeclampsia-like pregnancies with findings from human preeclamptic pregnancies by STE. The same algorithms were used to evaluate and compare the changes in echoes of human and rodents. Parameters of functionality such as global longitudinal strain (animal -23.54 ± 1.82% vs. -13.79 ± 0.57%, human -20.60 ± 0.47% vs. -15.45 ± 1.55%) as well as indications of morphological changes such as relative wall thickness (animal 0.20 ± 0.01 vs. 0.25 ± 0.01, human 0.34 ± 0.01 vs. 0.40 ± 0.02) are significantly altered in both species after preeclamptic pregnancies. Thus, the described rat model simulates the human situation quite well and is a valuable tool for future investigations regarding cardiovascular changes. STE is a unique technique that can be applied in animal models and humans with a high potential to uncover cardiovascular maladaptation and subtle pathologies.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
preeclampsia
en
dc.subject
speckle tracking echocardiography
en
dc.subject
cardiovascular dysfunction
en
dc.subject
animal models of human disease
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Speckle Tracking Echocardiography: New Ways of Translational Approaches in Preeclampsia to Detect Cardiovascular Dysfunction
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1162
dcterms.bibliographicCitation.doi
10.3390/ijms21031162
dcterms.bibliographicCitation.journaltitle
International Journal of Molecular Sciences
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
21
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32050556
dcterms.isPartOf.eissn
1422-0067