dc.contributor.author
Bäcker-Koduah, Priscilla
dc.contributor.author
Bellmann-Strobl, Judith
dc.contributor.author
Scheel, Michael
dc.contributor.author
Wuerfel, Jens
dc.contributor.author
Wernecke, Klaus-Dieter
dc.contributor.author
Dörr, Jan
dc.contributor.author
Brandt, Alexander Ulrich
dc.contributor.author
Paul, Friedemann
dc.date.accessioned
2020-03-24T12:32:59Z
dc.date.available
2020-03-24T12:32:59Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/27011
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-26772
dc.description.abstract
Objective: To investigate the associations between hypovitaminosis D and disease activity in a cohort of relapsing remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) patients.
Methods: In 51 RRMS and 2 CIS patients on stable interferon-β-1b (IFN-β-1b) treatment recruited to the EVIDIMS study (Efficacy of Vitamin D Supplementation in Multiple Sclerosis (NCT01440062) baseline serum vitamin D levels were evaluated. Patients were dichotomized based on the definition of vitamin D deficiency which is reflected by a < 30 vs. ≥ 30 ng/ml level of 25-hydroxyvitamin D (25(OH)D). Possible associations between vitamin D deficiency and both clinical and MRI features of the disease were analyzed.
Results: Median (25, 75% quartiles, Q) 25(OH)D level was 18 ng/ml (12, 24). Forty eight out of 53 (91%) patients had 25(OH)D levels < 30 ng/ml (p < 0.001). Patients with 25(OH)D ≥ 30 ng/ml had lower median (25, 75% Q) T2-weighted lesion counts [25 (24, 33)] compared to patients with 25(OH)D < 30 ng/ml [60 (36, 84), p = 0.03; adjusted for age, gender and disease duration: p < 0.001]. Expanded disability status scale (EDSS) score was negatively associated with serum 25(OH)D levels in a multiple linear regression, including age, sex, and disease duration (adjusted: p < 0.001).
Interpretation: Most patients recruited in the EVIDIMS study were vitamin D deficient. Higher 25(OH)D levels were associated with reduced T2 weighted lesion count and lower EDSS scores.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
multiple sclerosis
en
dc.subject
vitamin D deficiency
en
dc.subject
T2w lesion count
en
dc.subject
disease severity
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Vitamin D and Disease Severity in Multiple Sclerosis-Baseline Data From the Randomized Controlled Trial (EVIDIMS)
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
129
dcterms.bibliographicCitation.doi
10.3389/fneur.2020.00129
dcterms.bibliographicCitation.journaltitle
Frontiers in Neurology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media S.A.
dcterms.bibliographicCitation.volume
11
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32158426
dcterms.isPartOf.eissn
1664-2295