dc.contributor.author
Sletten, Eric T.
dc.contributor.author
Nuño, Manuel
dc.contributor.author
Guthrie, Duncan
dc.contributor.author
Seeberger, Peter H.
dc.date.accessioned
2020-01-27T09:21:41Z
dc.date.available
2020-01-27T09:21:41Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/26517
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-26277
dc.description.abstract
On-resin aggregation and incomplete amide bond formation are major challenges for solid-phase peptide synthesis that are difficult to be monitored in real-time. Incorporation of a pressure-based variable bed flow reactor into an automated solid-phase peptide synthesizer permitted real-time monitoring of resin swelling to determine amino acid coupling efficiency and on-resin aggregation.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
solid-phase peptidesynthesis
en
dc.subject
bed flow reactor
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
Real-time monitoring of solid-phase peptide synthesis using a variable bed flow reactor
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1039/c9cc08421e
dcterms.bibliographicCitation.journaltitle
Chemical Communications
dcterms.bibliographicCitation.number
97
dcterms.bibliographicCitation.pagestart
14598
dcterms.bibliographicCitation.pageend
14601
dcterms.bibliographicCitation.volume
55
dcterms.bibliographicCitation.url
https://doi.org/10.1039/C9CC08421E
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1364-548X
dcterms.isPartOf.zdb
1472881-3
