dc.contributor.author
Kratz, Harald
dc.contributor.author
Mohtashamdolatshahi, Azadeh
dc.contributor.author
Eberbeck, Dietmar
dc.contributor.author
Kosch, Olaf
dc.contributor.author
Hauptmann, Ralf
dc.contributor.author
Wiekhorst, Frank
dc.contributor.author
Taupitz, Matthias
dc.contributor.author
Hamm, Bernd
dc.contributor.author
Schnorr, Jörg
dc.date.accessioned
2020-01-20T14:42:00Z
dc.date.available
2020-01-20T14:42:00Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/26465
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-26225
dc.description.abstract
Magnetic particle imaging (MPI) is a new imaging technique that detects the spatial distribution of magnetic nanoparticles (MNP) with the option of high temporal resolution. MPI relies on particular MNP as tracers with tailored characteristics for improvement of sensitivity and image resolution. For this reason, we developed optimized multicore particles (MCP 3) made by coprecipitation via synthesis of green rust and subsequent oxidation to iron oxide cores consisting of a magnetite/maghemite mixed phase. MCP 3 shows high saturation magnetization close to that of bulk maghemite and provides excellent magnetic particle spectroscopy properties which are superior to Resovist® and any other up to now published MPI tracers made by coprecipitation. To evaluate the MPI characteristics of MCP 3 two kinds of tube phantoms were prepared and investigated to assess sensitivity, spatial resolution, artifact severity, and selectivity. Resovist® was used as standard of comparison. For image reconstruction, the regularization factor was optimized, and the resulting images were investigated in terms of quantifying of volumes and iron content. Our results demonstrate the superiority of MCP 3 over Resovist® for all investigated MPI characteristics and suggest that MCP 3 is promising for future experimental in vivo studies.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
magnetic particle imaging (MPI)
en
dc.subject
magnetic particle spectroscopy (MPS)
en
dc.subject
magnetic nanoparticles (MNP)
en
dc.subject
magnetic multicore particles (MCP)
en
dc.subject
coprecipitation
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
MPI Phantom Study with A High-Performing Multicore Tracer Made by Coprecipitation
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1466
dcterms.bibliographicCitation.doi
10.3390/nano9101466
dcterms.bibliographicCitation.journaltitle
Nanomaterials
dcterms.bibliographicCitation.number
10
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
9
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31623127
dcterms.isPartOf.eissn
2079-4991