dc.contributor.author
Granegger, Marcus
dc.contributor.author
Choi, Young
dc.contributor.author
Locher, Benedikt
dc.contributor.author
Aigner, Philipp
dc.contributor.author
Hubmann, Emanuel J.
dc.contributor.author
Lemme, Frithjof
dc.contributor.author
Cesarovic, Nikola
dc.contributor.author
Hübler, Michael
dc.contributor.author
Schweiger, Martin
dc.date.accessioned
2020-01-08T13:25:53Z
dc.date.available
2020-01-08T13:25:53Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/26349
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-26110
dc.description.abstract
The previously more frequently implanted pulsatile blood pumps (PBPs) showed higher recovery rates than the currently preferred rotary blood pumps (RBPs), with unclear causality. The aim of this study was to comparatively assess the capability of PBPs and RPBs to unload the left ventricle and maintain cardiac energetics as a possible implication for recovery. An RBP and a heartbeat synchronized PBP were alternately connected to isolated porcine hearts. Rotational speed of RBPs was set to different support levels. For PBP support, the start of ejection was phased to different points during the cardiac cycle, prescribed as percentage delays from 0% to 90%. Cardiac efficiency, quantified by the ratio of external work over myocardial oxygen consumption, was determined. For RBP support, higher degrees of RBP support correlated with lower left atrial pressures (LAP) and lower cardiac efficiency (r = 0.91 ± 0.12). In contrast, depending on the phase delay of a PBP, LAP and cardiac efficiency exhibited a sinusoidal relationship with the LAP minimum at 90% and efficiency maximum at 60%. Phasing of a PBP offers the possibility to maintain a high cardiac efficiency and simultaneously unload the ventricle. These results warrant future studies investigating whether optimized cardiac energetics promotes functional recovery with LVAD therapy.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
pulsatile blood pumps
en
dc.subject
rotary blood pumps
en
dc.subject
left atrial pressures
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Comparative analysis of cardiac mechano-energetics in isolated hearts supported by pulsatile or rotary blood pumps
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
20058
dcterms.bibliographicCitation.doi
10.1038/s41598-019-56344-8
dcterms.bibliographicCitation.journaltitle
Scientific Reports
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
Nature Publishing Group
dcterms.bibliographicCitation.volume
9
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31882656
dcterms.isPartOf.eissn
2045-2322