dc.contributor.author
Meißner, Sebastian
dc.contributor.author
Janssen, Jan-Carlo
dc.contributor.author
Prasad, Vikas
dc.contributor.author
Diederichs, Gerd
dc.contributor.author
Hamm, Bernd
dc.contributor.author
Brenner, Winfried
dc.contributor.author
Makowski, Marcus R.
dc.date.accessioned
2019-12-16T10:39:12Z
dc.date.available
2019-12-16T10:39:12Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/26261
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-26021
dc.description.abstract
The aim was to assess the performance of prostate 3T MRI for pelvic lymph node (LN) staging in prostate cancer (PCa), in comparison to 68Gallium-prostate specific membrane antigen PET-CT (68Ga-PSMA PET-CT) as reference standard for LN detection. 130 patients with PCa underwent non-contrast-enhanced multiparametric prostate 3T MRI and 68Ga-PSMA-PET-CT within 180 days at our institution. Overall, 187 LN metastases (n = 43 patients) detected by 68Ga-PSMA-PET-CT were characterized by calculating maximum standardized uptake value (SUVmax), area, diameter and anatomical location including iliac, obturator, presacral and inguinal region. MRI achieved an overall sensitivity, specificity, positive and negative predictive value of 81.6% (CI 71.1-88.9%), 98.6% (CI 97.6-99.2%), 73.5% (CI 52.1-87.6%) and 99.5% (CI 98.8-99.8%), respectively. On a region-based analysis, detection rates differed non-significantly (ps > 0.12) in the anatomical regions. On a size-dependent analysis, detection of LN > 10 mm did not differ significantly (ps > 0.09) from LN ≤ 10 mm. In comparison to single T1 sequence evaluation, additional use of the T2 weighted sequences did not improve the overall performance significantly (p > 0.05). 3T prostate MRI represented an accurate tool for the detection of LN compared to 68Ga-PSMA-PET-CT. Especially for LN metastases smaller than 10 mm, MRI was less accurate compared to 68Ga-PSMA-PET-CT.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Prostate cancer
en
dc.subject
68Ga-PSMA-PET-CT
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Accuracy of standard clinical 3T prostate MRI for pelvic lymph node staging: Comparison to 68Ga-PSMA PET-CT
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
10727
dcterms.bibliographicCitation.doi
10.1038/s41598-019-46386-3
dcterms.bibliographicCitation.journaltitle
Scientific Reports
dcterms.bibliographicCitation.originalpublishername
Nature Publishing Group
dcterms.bibliographicCitation.volume
9
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31341209
dcterms.isPartOf.eissn
2045-2322