dc.contributor.author
Martín, Sandra Pinzón
dc.contributor.author
Seeberger, Peter H.
dc.contributor.author
Silva, Daniel Varón
dc.date.accessioned
2019-12-06T11:19:26Z
dc.date.available
2019-12-06T11:19:26Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/26062
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-25821
dc.description.abstract
Mucins and mucin-like molecules are highly O-glycosylated proteins present on the cell surface of mammals and other organisms. These glycoproteins are highly diverse in the apoprotein and glycan cores and play a central role in many biological processes and diseases. Mucins are the most abundant macromolecules in mucus and are responsible for its biochemical and biophysical properties. Mucin-like molecules cover various protozoan parasites, fungi and viruses. In humans, modifications in mucin glycosylation are associated with tumors in epithelial tissue. These modifications allow the distinction between normal and abnormal cell conditions and represent important targets for vaccine development against some cancers. Mucins and mucin-like molecules derived from pathogens are potential diagnostic markers and targets for therapeutic agents. In this review, we summarize the distribution, structure, role as immunomodulators, and the correlation of human mucins with diseases and perform a comparative analysis of mucins with mucin-like molecules present in human pathogens. Furthermore, we review the methods to produce pathogenic and human mucins using chemical synthesis and expression systems. Finally, we present applications of mucin-like molecules in diagnosis and prevention of relevant human diseases.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
mucin-like molecules
en
dc.subject
O-glycoproteins
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
Mucins and Pathogenic Mucin-Like Molecules Are Immunomodulators During Infection and Targets for Diagnostics and Vaccines
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
710
dcterms.bibliographicCitation.doi
10.3389/fchem.2019.00710
dcterms.bibliographicCitation.journaltitle
Frontiers in Chemistry
dcterms.bibliographicCitation.volume
7
dcterms.bibliographicCitation.url
https://doi.org/10.3389/fchem.2019.00710
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2296-2646