dc.contributor.author
Rancourt, Rebecca C.
dc.contributor.author
Ott, Raffael
dc.contributor.author
Schellong, Karen
dc.contributor.author
Melchior, Kerstin
dc.contributor.author
Zirka, Thomas
dc.contributor.author
Henrich, Wolfgang
dc.contributor.author
Plagemann, Andreas
dc.date.accessioned
2019-10-30T10:33:53Z
dc.date.available
2019-10-30T10:33:53Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/25840
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-25601
dc.description.abstract
Obesity and diabetes are at an epidemic rate, as well as growing incidences of gestational diabetes mellitus (GDM) which causes pregnancy risks, and harm in both maternal and child health. It remains unclear which molecular mechanisms are driving the functional differences between visceral and subcutaneous fat and how these types directly affect an individual's health outcome. Paired abdominal subcutaneous and omental visceral adipose tissue were collected from women with GDM (n = 20) and with normal glucose tolerance (NGT, n = 22) during planned caesarian section. Both groups had similar maternal age (average 32.5 years) and BMI at delivery (average 33.3 kg/m2). Adipose tissue mRNA expression analyses of insulin signalling genes: PI3KCA, PI3KR1, IRS1 and IRS2 showed significantly decreased PI3KR1 expression (-23%) in visceral fat in GDM with no association to promoter DNA methylation. Reduced visceral fat PI3KR1 expression appears to be a pathogenic factor in GDM but not through altered promoter methylation.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
DNA methylation
en
dc.subject
phosphatidylinositol 3-kinase
en
dc.subject
adipose tissue
en
dc.subject
gestational diabetes mellitus
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Visceral adipose tissue alteration of PI3KR1 expression is associated with gestational diabetes but not promoter DNA methylation
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1080/21623945.2019.1675239
dcterms.bibliographicCitation.journaltitle
Adipocyte
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
Taylor & Francis Group
dcterms.bibliographicCitation.pagestart
339
dcterms.bibliographicCitation.pageend
346
dcterms.bibliographicCitation.volume
8
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31608772
dcterms.isPartOf.eissn
2162-397X