dc.contributor.author
Natu, Vaidehi S.
dc.contributor.author
Kirilina, Evgeniya
dc.contributor.author
Gomez, Jesse
dc.contributor.author
Barnett, Michael
dc.contributor.author
Jeska, Brianna
dc.contributor.author
Jaeger, Carsten
dc.contributor.author
Zhen, Zonglei
dc.contributor.author
Cox, Siobhan
dc.contributor.author
Weiner, Kevin S.
dc.contributor.author
Weiskopf, Nikolaus [u.v.m.]
dc.date.accessioned
2019-10-24T13:33:30Z
dc.date.available
2019-10-24T13:33:30Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/25797
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-25558
dc.description.abstract
Human cortex appears to thin during childhood development. However, the underlying microstructural mechanisms are unknown. Using functional magnetic resonance imaging (fMRI), quantitative MRI (qMRI), and diffusion MRI (dMRI) in children and adults, we tested what quantitative changes occur to gray and white matter in ventral temporal cortex (VTC) from childhood to adulthood, and how these changes relate to cortical thinning. T1 relaxation time from qMRI and mean diffusivity (MD) from dMRI provide independent and complementary measurements of microstructural properties of gray and white matter tissue. In face- and character-selective regions in lateral VTC, T1 and MD decreased from age 5 to adulthood in mid and deep cortex, as well as in their adjacent white matter. T1 reduction also occurred longitudinally in children’s brain regions. T1 and MD decreases 1) were consistent with tissue growth related to myelination, which we verified with adult histological myelin stains, and 2) were correlated with apparent cortical thinning. In contrast, in place-selective cortex in medial VTC, we found no development of T1 or MD after age 5, and thickness was related to cortical morphology. These findings suggest that lateral VTC likely becomes more myelinated from childhood to adulthood, affecting the contrast of MR images and, in turn, the apparent gray–white boundary. These findings are important because they suggest that VTC does not thin during childhood but instead gets more myelinated. Our data have broad ramifications for understanding both typical and atypical brain development using advanced in vivo quantitative measurements and clinical conditions implicating myelin.
en
dc.format.extent
10 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
cortical thickness
en
dc.subject
quantitative MRI
en
dc.subject
diffusion MRI
en
dc.subject
longitudinal
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
Apparent thinning of human visual cortex during childhood is associated with myelination
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1073/pnas.1904931116
dcterms.bibliographicCitation.journaltitle
Proceedings of the National Academy of Sciences of the United States of America
dcterms.bibliographicCitation.number
41
dcterms.bibliographicCitation.pagestart
20750
dcterms.bibliographicCitation.pageend
20759
dcterms.bibliographicCitation.volume
116
dcterms.bibliographicCitation.url
https://doi.org/10.1073/pnas.1904931116
refubium.affiliation
Erziehungswissenschaft und Psychologie
refubium.affiliation.other
Arbeitsbereich Neurocomputation and Neuroimaging
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
0027-8424
dcterms.isPartOf.eissn
1091-6490
refubium.resourceType.provider
WoS-Alert