dc.contributor.author
Hoffmann, Jan
dc.contributor.author
Kreutz, Katharina Maria
dc.contributor.author
Csapó-Schmidt, Christoph
dc.contributor.author
Becker, Nils
dc.contributor.author
Kunte, Hagen
dc.contributor.author
Fekonja, Lucius Samo
dc.contributor.author
Jadan, Anas
dc.contributor.author
Wiener, Edzard
dc.date.accessioned
2019-08-09T11:14:06Z
dc.date.available
2019-08-09T11:14:06Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/25252
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-3957
dc.description.abstract
Background: Elevation of intracranial pressure in idiopathic intracranial hypertension induces an edema of the prelaminar section of the optic nerve (papilledema). Beside the commonly observed optic nerve sheath distention, information on a potential pathology of the retrolaminar section of the optic nerve and the short-term effect of normalization of intracranial pressure on these abnormalities remains scarce.
Methods: In this exploratory study 8 patients diagnosed with idiopathic intracranial hypertension underwent a MRI scan (T2 mapping) as well as a diffusion tensor imaging analysis (fractional anisotropy and mean diffusivity). In addition, the clinical presentation of headache and its accompanying symptoms were assessed. Intracranial pressure was then normalized by lumbar puncture and the initial parameters (MRI and clinical features) were re-assessed within 26 h.
Results: After normalization of CSF pressure, the morphometric MRI scans of the optic nerve and optic nerve sheath remained unchanged. In the diffusion tensor imaging, the fractional anisotropy value was reduced suggesting a tissue decompression of the optic nerve after lumbar puncture. In line with these finding, headache and most of the accompanying symptoms also improved or remitted within that short time frame.
Conclusion: The findings support the hypothesis that the elevation of intracranial pressure induces a microstructural compression of the optic nerve impairing axoplasmic flow and thereby causing the prelaminar papilledema. The microstructural compression of the optic nerve as well as the clinical symptoms improve within hours of normalization of intracranial pressure.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
idiopathic intracranial hypertension
en
dc.subject
intracranial pressure
en
dc.subject
lumbar puncture
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
The effect of CSF drain on the optic nerve in idiopathic intracranial hypertension
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
59
dcterms.bibliographicCitation.doi
10.1186/s10194-019-1004-1
dcterms.bibliographicCitation.journaltitle
The Journal of Headache and Pain
dcterms.bibliographicCitation.originalpublishername
BMC
dcterms.bibliographicCitation.volume
20
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31122204
dcterms.isPartOf.issn
1129-2369
dcterms.isPartOf.eissn
1129-2377