dc.contributor.author
Schalla, Martha A.
dc.contributor.author
Stengel, Andreas
dc.date.accessioned
2019-06-27T08:17:08Z
dc.date.available
2019-06-27T08:17:08Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24939
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2699
dc.description.abstract
Anorexia nervosa (AN) is a severe eating disorder affecting around 1 per 100 persons. However, the knowledge about its underlying pathophysiology is limited. To address the need for a better understanding of AN, an animal model was established early on in the late 1960's: the activity-based anorexia (ABA) model in which rats have access to a running wheel combined with restricted food access leading to self-starving/body weight loss and hyperactivity. Both symptoms, separately or combined, can also be found in patients with AN. The aim of this systematic review was to compile the current knowledge about this animal model as well as to address gaps in knowledge. Using the data bases of PubMed, Embase and Web of science 102 publications were identified meeting the search criteria. Here, we show that the ABA model mimics core features of human AN and has been characterized with regards to brain alterations, hormonal changes as well as adaptations of the immune system. Moreover, pharmacological interventions in ABA animals and new developments, such as a chronic adaptation of the ABA model, will be highlighted. The chronic model might be well suited to display AN characteristics but should be further characterized. Lastly, limitations of the model will be discussed.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
eating disorder
en
dc.subject
food restriction
en
dc.subject
hyperactivity
en
dc.subject
self-starvation
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Activity Based Anorexia as an Animal Model for Anorexia Nervosa–A Systematic Review
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
69
dcterms.bibliographicCitation.doi
10.3389/fnut.2019.00069
dcterms.bibliographicCitation.journaltitle
Frontiers in Nutrition
dcterms.bibliographicCitation.originalpublishername
Frontiers Media S.A.
dcterms.bibliographicCitation.volume
6
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31165073
dcterms.isPartOf.eissn
2296-861X