Background: An early detection of Osteoarthritis is urgently needed and still not possible until today. The aim of
the study was to assess whether molecular biomarkers of cartilage turnover are associated with longitudinal change
in knee cartilage thickness during a 2 year period in individuals with increased risk of developing knee
osteoarthritis. A secondary aim was to assess whether prior knee injury or subjective patient-reported outcomes at
baseline (BL) were associated with articular cartilage changes. Nineteen volleyball players (mean age 46.5 ± 4.9 years,
47% male) with a 30-year history of regular high impact training were recruited. The serum biomarkers Cpropeptide
of type II procollagen (CPII), cartilage oligomeric matrix protein (COMP), collagenase generated carboxy-terminal
neoepitope of type II collagen (sC2C), cartilage intermediate layer protein 2 (CILP-2), and the urine biomarkers Ctelopeptide
of type II collagen (CTX-II) and collagenase-generated peptide(s) of type II collagen (C2C-HUSA) were
assessed at BL and at 2 year follow up (FU). Femorotibial cartilage thinning, thickening and absolute thickness
change between BL and FU was evaluated from magnetic resonance imaging. Subjective clinical status at BL was
evaluated by the International Knee Documentation Committee Subjective Knee Form and the Short-Form 36
Physical Component Score.
Results: CILP-2 was significantly higher at FU and linearly associated with the absolute cartilage thickness change
during the experimental period. Prior injury was a predictor of increased absolute cartilage thickness change.
Conclusion: Measuring the change in the cartilage biomarker CILP-2 might be a valid and sensitive method to
detect early development of knee osteoarthritis as CILP-2 appears to be related to cartilage thickness loss in certain
individuals with increased risk of developing knee osteoarthritis. Prior knee injury may be predictive of increased
articular cartilage thickness change.
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Association between changes in molecular biomarkers of cartilage matrix turnover and changes in knee articular cartilage: a longitudinal pilot study
Journal of Experimental Orthopaedics
Charité - Universitätsmedizin Berlin