Background: Anti-tumour immune competence has an impact in hepatocarcinogenesis and success of anti-cancer
therapies. Tumour-infiltrating lymphocytes (TILs) and monocytes/macrophages (TAMs) are proposed to have significance
in cancer. However, there is only limited data concerning their impact on patient outcome and survival in hepatocellular
Methods: Frequencies of CD68+, CD163+M2-polarized TAMs and TILs were measured in de novo HCC tumours in noncirrhosis
(n = 58) using immunohistology and correlated to patients’ clinicopathological characteristics and survival rates.
Results: Patients with tumours marked by appearance of TILs and CD68+ TAMs showed an improved 1-, 3- and 5-year
recurrence-free survival (all p ≤ 0.05). CD68+ TAMs were associated with reduced incidence of recurrent and multifocal
disease. Conversely, CD163+ TAMs were associated with multifocal HCC and lymphangiosis carcinomatosa (all p ≤ 0.05).
Conclusions: TILs and CD68+ TAMs are associated with multiple tumour characteristics and patient survival in HCC.
However, there is only scarce data about the biology underlying their mechanistic involvement in human tumour
progression. Thus, experimental data on functional links might help develop novel immunologic checkpoint inhibitor
targets for liver cancer.
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Immunologic cellular characteristics of the tumour microenvironment of hepatocellular carcinoma drive patient outcomes
World Journal of Surgical Oncology
Charité - Universitätsmedizin Berlin