dc.contributor.author
Dabrowski, Alexander N.
dc.contributor.author
Conrad, Claudia
dc.contributor.author
Behrendt, Ulrike
dc.contributor.author
Shrivastav, Anshu
dc.contributor.author
Baal, Nelli
dc.contributor.author
Wienhold, Sandra M.
dc.contributor.author
Hackstein, Holger
dc.contributor.author
N'Guessan, Philippe D.
dc.contributor.author
Aly, Sahar
dc.contributor.author
Reppe, Katrin
dc.contributor.author
Suttorp, Norbert
dc.contributor.author
Zahlten, Janine
dc.date.accessioned
2019-06-11T12:51:20Z
dc.date.available
2019-06-11T12:51:20Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24735
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2495
dc.description.abstract
Peptidoglycan (PGN) recognition proteins (PGLYRPs) are a highly conserved group of host defense proteins in insects and mammals that sense bacterial cell wall PGN and act bactericidally or cleave PGN by amidase function. Streptococcus (S.) pneumoniae is one of the top five killers worldwide and causes, e.g., pneumonia, endocarditis, meningitis and sepsis. S. pneumoniae accounts for approximately 1.5-2 million deaths every year. The risk of antibiotic resistance and a general poor prognosis in young children and elderly people have led to the need for new treatment approaches. To the best of our knowledge, there is no report on the relevance of PGLYRP2 in lung infections. Therefore, we infected mice deficient for PGLYRP2 transnasally with S. pneumoniae and examined the innate immune response in comparison to WT animals. As expected, PGLYRP2-KO animals had to be sacrificed earlier than their WT counterparts, and this was due to higher bacteremia. The higher bacterial load in the PGLYRP2-KO mice was accomplished with lower amounts of proinflammatory cytokines in the lungs. This led to an abolished recruitment of neutrophils into the lungs, the spread of bacteria and the subsequent aggravated course of the disease and early mortality of the PGLYRP2-KO mice. These data suggest a substantial role of PGLYRP2 in the early defense against S. pneumoniae infection, and PGLYRP2 might also affect other infections in the lungs.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
infectious diseases
en
dc.subject
innate immunity
en
dc.subject
S. pneumoniae
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Peptidoglycan Recognition Protein 2 Regulates Neutrophil Recruitment Into the Lungs After Streptococcus pneumoniae Infection
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
199
dcterms.bibliographicCitation.doi
10.3389/fmicb.2019.00199
dcterms.bibliographicCitation.journaltitle
Frontiers in Microbiology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media S.A.
dcterms.bibliographicCitation.volume
10
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
30837960
dcterms.isPartOf.issn
1664-302X