dc.contributor.author
Nienen, Mikalai
dc.contributor.author
Stervbo, Ulrik
dc.contributor.author
Mölder, Felix
dc.contributor.author
Kaliszczyk, Sviatlana
dc.contributor.author
Kuchenbecker, Leon
dc.contributor.author
Gayova, Ludmila
dc.contributor.author
Schweiger, Brunhilde
dc.contributor.author
Jürchott, Karsten
dc.contributor.author
Hecht, Jochen
dc.contributor.author
Neumann, Avidan U.
dc.contributor.author
Rahmann, Sven
dc.contributor.author
Westhoff, Timm
dc.contributor.author
Reinke, Petra
dc.contributor.author
Thiel, Andreas
dc.contributor.author
Babel, Nina
dc.date.accessioned
2019-06-07T09:28:22Z
dc.date.available
2019-06-07T09:28:22Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24710
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2470
dc.description.abstract
Influenza vaccination is a common approach to prevent seasonal and pandemic influenza. Pre-existing antibodies against close viral strains might impair antibody formation against previously unseen strains-a process called original antigenic sin. The role of this pre-existing cellular immunity in this process is, despite some hints from animal models, not clear. Here, we analyzed cellular and humoral immunity in healthy individuals before and after vaccination with seasonal influenza vaccine. Based on influenza-specific hemagglutination inhibiting (HI) titers, vaccinees were grouped into HI-negative and -positive cohorts followed by in-depth cytometric and TCR repertoire analysis. Both serological groups revealed cross-reactive T-cell memory to the vaccine strains at baseline that gave rise to the majority of vaccine-specific T-cells post vaccination. On the contrary, very limited number of vaccine-specific T-cell clones was recruited from the naive pool. Furthermore, baseline quantity of vaccine-specific central memory helper T-cells and clonotype richness of this population directly correlated with the vaccination efficacy. Our findings suggest that the deliberate recruitment of pre-existing cross-reactive cellular memory might help to improve vaccination outcome.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
influenza vaccination
en
dc.subject
vaccination efficacy
en
dc.subject
pre-existing cross-reactive T-cells
en
dc.subject
central memory T-cell
en
dc.subject
clonotype diversity
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
The Role of Pre-existing Cross-Reactive Central Memory CD4 T-Cells in Vaccination With Previously Unseen Influenza Strains
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
593
dcterms.bibliographicCitation.doi
10.3389/fimmu.2019.00593
dcterms.bibliographicCitation.journaltitle
Frontiers in Immunology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media S.A.
dcterms.bibliographicCitation.volume
10
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31019503
dcterms.isPartOf.issn
1664-3224